Anti-53BP2 apoptosis-stimulating protein of p53 2, Anti-TP53BP2, Anti-tumor protein p53-binding protein 2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Western blot analysis of Hek293 or 3T3-L1 adipocyte cell lysates was performed using monoclonal mouse anti-ASPP2 as the primary.
Allgemeine Beschreibung
Monoclonal Anti-ASPP2 (mouse IgG1 isotype) is derived from the hybridoma DX 54.10 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice. Apoptosis-stimulating protein of p53 (ASPP) family of proteins contains three members, ASPP1, ASPP2 and iASPP, which interact via their C-terminal region with p53 and modulate its activity.
Biochem/physiol Actions
ASPP2 is a tumor suppressor that activates p53. ASPP2 also regulates Par-3 which subsequently modulates the proliferation and polarity of neural progenitor cells during CNS development. Furthermore, ASPP2 interacts with active Ras to induce p53 mediated cell death. ASPP2 is known to function as a biomarker for invasive pituitary adenomas.
Anti-53BP2 apoptosis-stimulating protein of p53 2, Anti-TP53BP2, Anti-tumor protein p53-binding protein 2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
