Anti-RAI, Anti-Rel-associated Inhibitor, Anti-Inhibitory Member of the Apoptosis-stimulating Protein of p53 Family Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-iASPP antibody produced in mouse has been used in:
- immunoblotting
- immunocytochemistry
- immunoprecipitation
Allgemeine Beschreibung
Monoclonal Anti-iASPP (mouse IgG1 isotype) is derived from the hybridoma LXO49, produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with a recombinant protein encoding residues of human iASPP. The ASPP family of proteins contains three members, ASSP1, ASSP2 and iASPP. iASPP is also known as REL associated inhibitor (RAI). iASPP exists as a 100 kDa form and as a 70 kDa form (iASPP/RAI). It is found both in the nucleus and cytoplasm, while iASPP/RAI is mainly cytosolic. PPP1R13L (protein phosphatase 1 regulatory subunit 13 like) codes for iASPP, that is located on human chromosome 19q13.
Biochem/physiol Actions
PPP1R13L (protein phosphatase 1 regulatory subunit 13 like)/iASPP inhibits p53-mediated cell death. It interacts and inhibits NFkB p65 RelA. It may act as a therapeutic target for bladder cancer (BC). It modulates cell proliferation and apoptosis. iASPP plays a key role in breast cancer and acute leukemia.
Anti-RAI, Anti-Rel-associated Inhibitor, Anti-Inhibitory Member of the Apoptosis-stimulating Protein of p53 Family Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
