IVACHTIN

745046-84-8

CAS-Nr.: 745046-84-8

Englisch Name:: IVACHTIN

Synonyma:: IVACHTIN;2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-;2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate;modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced

CBNumber:: CB82459565

Summenformel:: C20H21N3O7S

Molgewicht:: 447.46

MOL-Datei:: 745046-84-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 63

IVACHTIN Eigenschaften

Siedepunkt:: 665.0±65.0 °C(Predicted)

Dichte: 1.459±0.06 g/cm3(Predicted)

storage temp.: Desiccate at +4°C

L?slichkeit: Limited solubility, soluble in DMSO or DMF

pka: 1.87±0.20(Predicted)

Aggregatzustand: Off-white solid

Farbe: off-white

InChI: 1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3

InChIKey: MWXJJTMEUGWKKY-UHFFFAOYSA-N

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

IVACHTIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3.

Allgemeine Beschreibung

A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC₅₀ = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.

Biochem/physiol Actions

Cell permeable: yes

IVACHTIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

IVACHTIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 63)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15838	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2782	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12306	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58

IVACHTIN
2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate
2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-
2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
745046-84-8
Inhibitor of caspase-3.

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