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Linaclotide

Linaclotide Struktur
851199-59-2
CAS-Nr.
851199-59-2
Englisch Name:
Linaclotide
Synonyma:
Linacllotide;Argpessin;inaclotide;Linalotide;Rinalodipine Acetate;CY-14;Liclotide;Linaclotide;Linaelotide;Linaelotide Acetate
CBNumber:
CB82498818
Summenformel:
C59H79N15O21S6
Molgewicht:
1526.74
MOL-Datei:
851199-59-2.mol

Linaclotide Eigenschaften

Schmelzpunkt:
231-235°C (dec.)
Siedepunkt:
2045.0±65.0 °C(Predicted)
Dichte
1.60
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
L?slichkeit
DMSO (Slightly, Heated), Methanol ((Slightly, Heated)), Water (Slightly, Heated)
pka
3.05±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White
Stabilit?t:
Hygroscopic
InChIKey
KXGCNMMJRFDFNR-VRMHCMCOSA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  WGK 3
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Giftige Stoffe Daten 851199-59-2(Hazardous Substances Data)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Linaclotide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.

Verwenden

Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.

Biologische Funktion

Linaclotide works by increasing fluid in your intestines and helping speed up movement of food through the gut. Linaclotide may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements.

Nebenwirkungen

Side effects include:Diarrhea, abdominal pain, flatulence, abdominal distension, viral gastroenteritis, headache, upper respiratory tract infection, sinusitis

Linaclotide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Linaclotide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 360)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Shengnuo Biopharm Co.,Ltd
+8613880038419
leili@snbiopharm.com China 70 58
AFINE CHEMICALS LIMITED
+86-571-85134551
info@afinechem.com China 15083 58
Apextide Co Ltd
+8615300650552
info@apextide.com China 91 58
BJV BIOTECH LTD
+86-0755-23089946 +8619006605307
bjvbiotech@163.com China 67 58
Hainan Fubai Trading Co., LTD
+undefined852-57423927
13313004729@163.com China 103 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533
Brad@rongnabiotech.com China 3365 58
Hydebio Labs Co.,Limited
+86-18100690299 +86-18100690299
mrkt@hydebiolabs.com China 108 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Shanghai Affida new material science and technology center
+undefined15081010295
admin@oudaxin.com China 114 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368
sales@sjar-tech.com China 529 58

851199-59-2()Verwandte Suche:


  • Linaclotide
  • Linaelotide Acetate
  • Linaelotide
  • CY-14
  • Liclotide
  • L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
  • Linaclotide USP/EP/BP
  • L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosylChemicalbook-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
  • Linaclotide D4Q: What is Linaclotide D4 Q: What is the CAS Number of Linaclotide D4 Q: What is the storage condition of Linaclotide D4 Q: What are the applications of Linaclotide D4
  • Rinalodipine Acetate
  • Linaclotide/Linaelotide Acetate
  • Linaclotide (free base)
  • Linaclotide, 10 mM in DMSO
  • (2S)-2-[[(1R,4S,7S,13S,16R,21R,24R,27S,30S,33R,38R,44S)-21-amino-13-(2-amino-2-oxoethyl)-27-(2-carboxyethyl)-44-[(1R)-1-hydroxyethyl]-30-[(4-hydroxyphenyl)methyl]-4-methyl-3,6,12,15,22,25,28,31,40,43,46,51-dodecaoxo-18,19,35,36,48,49-hexathia-2,5,11,14,23,26,29,32,39,42,45,52-dodecazatetracyclo[22.22.4.216,33.07,11]dopentacontane-38-carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acid
  • ((3S,6R,15R,20R,23S,26R,29R,32R,37R,40S,45aS)-32-Amino-40-(2-amino-2-oxoethyl)-26-(2-carboxyethyl)-23-(4-hydroxybenzyl)-9-((R)-1-hydroxyethyl)-3-methyl-1,4,7,10,13,22,25,28,31,38,41,47-dodecaoxotetracontahydro-19H-37,20-(epiminomethano)-6,29-(methanodithiomethano)pyrrolo[2,1-s][1,2,27,28]tetrathia[5,8,11,14,17,20,23,32,35,38,41]undecaazacyclotritetracontine-15-carbonyl)-L-tyrosine
  • Linaclotide Acetate / Linaclotide
  • Argpessin
  • inaclotide
  • Linacllotide
  • Linalotide
  • 851199-59-2
  • C59H79N15O21S6
  • C59H78N16O22S6
  • Inhibitors
  • 851199-59-2
  • APIs
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