xav-939
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- CAS-Nr.
- 284028-89-3
- Englisch Name:
- xav-939
- Synonyma:
- XAV d;CS-300;xav-939;NVP-XAV 939;SteMolecule;XAV 939, >=98%;XAV-939 ，S1180;XAV-939;XAV 939;xav-939 USP/EP/BP;XAV 939/NVP-XAV939
- CBNumber:
- CB82501008
- Summenformel:
- C14H11F3N2OS
- Molgewicht:
- 312.31
- MOL-Datei:
- 284028-89-3.mol
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xav-939 Eigenschaften
- Siedepunkt:
- 429.3±55.0 °C(Predicted)
- Dichte
- 1.5
- Flammpunkt:
- 213.4℃
- storage temp.
- room temp
- L?slichkeit
- DMSO: soluble5mg/mL, clear
- Aggregatzustand
- powder
- pka
- 0.23±0.20(Predicted)
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChI
- 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
- InChIKey
- KLGQSVMIPOVQAX-UHFFFAOYSA-N
- SMILES
- FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
xav-939 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
Biochem/physiol Actions
XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.
xav-939 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
xav-939 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 245)Lieferanten
- 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
- XAV-939;XAV 939
- xav-939
- 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
- XAV 939/NVP-XAV939
- XAV 939, >=98%
- SteMolecule
- 1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one
- NVP-XAV 939
- 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol
- XAV 939 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
- 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
- XAV-939, 98%, a selective Wnt pathway β-catenin-mediated transcription inhibitor
- XAV d
- 4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-
- xav-939 USP/EP/BP
- CS-300
- 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
- 2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one
- XAV-939 284028-89-3
- poly ADP ribose polymerase,PARP,Inhibitor,β-catenin,inhibit,Beta catenin,XAV-939,XAV 939
- 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
- XAV939, Tankyrase inhibitor
- XAV-939, 10 mM in DMSO
- XAV-939 ，S1180
- 3,5,7,8-tetrahydro-2-[4-(trifluorinemethyl)phenyl]-4H-thiopyrano[4,3-D]pyrimidine-4-one
- 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiofuranbenzo[4,3-D]pyrimidine-4-one
- 284028-89-3
- C14H11F3N2OS
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Aromatics
- API
