Autotaxin Inhibitor Screening Assay Kit Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Autotaxin (ATX, Ectonucleotide Pyrophosphatase/Phosphodiesterase-
2, ENPP-
2, Lysophospholipase D) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-
coupled receptors and induces a variety of biological responses, such as neurogenesis, angiogenesis, smooth-
muscle contraction, platelet aggregation, and wound healing. ATX-
LPA signaling is involved in a range of pathologies including tumor progression and inflammation. Cayman’s Autotaxin Inhibitor Screening Assay provides a convenient method for screening human ATX inhibitors. ATX cleaves
bis-
(
p-nitrophenyl) phosphate liberating
p-nitrophenol, a yellow product that is measured at 405-
415 nm.
Autotaxin Inhibitor Screening Assay Kit Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
