WP1066
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- CAS-Nr.
- 857064-38-1
- Englisch Name:
- WP1066
- Synonyma:
- WP1066;CS-604;WP1066, >=99%;WP1066 ，S2796;WP1066/WP-1066;WP1066 USP/EP/BP;STAT Inhibitor III;WP1066, 10 mM in DMSO;WP1066 (DMSO solution);WP1066; WP 1066;WP-1066
- CBNumber:
- CB82616030
- Summenformel:
- C17H14BrN3O
- Molgewicht:
- 356.22
- MOL-Datei:
- 857064-38-1.mol
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WP1066 Eigenschaften
- Schmelzpunkt:
- 90-93oC
- Siedepunkt:
- 569.9±50.0 °C(Predicted)
- Dichte
- 1.425
- storage temp.
- +2C to +8C
- L?slichkeit
- Soluble in DMSO (up to at least 25 mg/ml)
- Aggregatzustand
- Off-white solid
- pka
- 11.00±0.46(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- 1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
- InChIKey
- VFUAJMPDXIRPKO-LQELWAHVSA-N
- SMILES
- Brc1nc(ccc1)\C=C(\C(=O)N[C@@H](C)c2ccccc2)/C#N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 2 |
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| HS Code |
29333990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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WP1066 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
WP1066 is a cell-
permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-
MG and U373-
MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-
MG (IC
50 = 5.6 μM) and U373-
MG (IC
50 = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-
brain barrier, and demonstrates
in vivo activity, including immune activation as indicated by the up-
regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.
Verwenden
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.
WP1066 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
WP1066 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 177)Lieferanten
857064-38-1()Verwandte Suche:
- WP1066
- (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
- WP1066/WP-1066
- (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
- (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066
- WP1066, >=99%
- wp1066(STAT Inhibitor III)
- Stat3 Inhibitor III, WP1066
- (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide
- WP1066 USP/EP/BP
- WP1066, 98%, a novel inhibitor of JAK2 and STAT3
- CS-604
- WP1066; WP 1066;WP-1066
- STAT Inhibitor III
- 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-, (2E)-
- WP-1066 STAT3 Inhibitor III WP1066
- WP1066 (DMSO solution)
- (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide , WP1066
- WP1066, JAK/STAT3 inhibitor
- WP1066, 10 mM in DMSO
- WP1066 ，S2796
- 857064-38-1
- C17H14ON3Br
- Inhibitors
- JAK
- STAT
- Inhibitor
- API
