5-Butyl-1H-pyrazole-3-carboxylic acid
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- CAS-Nr.
- 92933-48-7
- Englisch Name:
- 5-Butyl-1H-pyrazole-3-carboxylic acid
- Synonyma:
- LUF6283;3-butyl-1H-pyrazole-5-carboxylic acid;5-Butyl-1H-pyrazole-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 5-butyl-
- CBNumber:
- CB82647450
- Summenformel:
- C8H12N2O2
- Molgewicht:
- 168.19
- MOL-Datei:
- 92933-48-7.mol
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5-Butyl-1H-pyrazole-3-carboxylic acid Eigenschaften
- Schmelzpunkt:
- 166-167 °C
- Siedepunkt:
- 385.8±30.0 °C(Predicted)
- Dichte
- 1+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO: soluble10mg/mL (clear solution; warmed)
- Aggregatzustand
- powder
- pka
- 15.44±0.10(Predicted)
- Farbe
- white to beige
5-Butyl-1H-pyrazole-3-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
LUF6283 is a partial agonist of GPR109A/HCA
2 G protein-coupled receptors (K
i = 0.55 μM in a radioligand binding assay). It stimulates [
35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA
2 receptors (EC
50s = 3.1 and 0.32 μM, respectively).
In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.
Verwenden
LUF 6283 is a partial agonist of HCA2 and is a promising drug candidate to achieve a beneficial lipid lowering effect of niacin, ultimately treating dyslipidemic disorders.
5-Butyl-1H-pyrazole-3-carboxylic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Butyl-1H-pyrazole-3-carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 44)Lieferanten
- 5-Butyl-1H-pyrazole-3-carboxylic acid
- 3-butyl-1H-pyrazole-5-carboxylic acid
- 1H-Pyrazole-3-carboxylic acid, 5-butyl-
- LUF6283
- 92933-48-7
