L 2-401
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- CAS-Nr.
- 883050-24-6
- Englisch Name:
- L 2-401
- Synonyma:
- CS-563;L 2-401;CCG 50014;CCG50014;CCG 50014;CCG-50014 >=98% (HPLC);CCG-50014, 10 mM in DMSO;4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione;4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione;1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-;Regulators of G-protein Signaling,Regulator of G-protein Signaling,RGS Protein,CCG-50014,inhibit,CCG50014,Inhibitor
- CBNumber:
- CB82657938
- Summenformel:
- C16H13FN2O2S
- Molgewicht:
- 316.35
- MOL-Datei:
- 883050-24-6.mol
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L 2-401 Eigenschaften
- Dichte
- 1.398±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3
- InChIKey
- QUIIIYITNGOFEI-UHFFFAOYSA-N
- SMILES
- Fc1ccc(cc1)C[n]2[c]([s][n]([c]2=O)c3ccc(cc3)C)=O
L 2-401 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC
50 = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα
0, while blocking GTPase activity and Gα
0-dependent translocation of RGS4 to the membrane.
L 2-401 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
L 2-401 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 91)Lieferanten
- 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
- CCG 50014
- L 2-401
- 1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-
- 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione
- CCG50014;CCG 50014
- CS-563
- CCG-50014 >=98% (HPLC)
- Regulators of G-protein Signaling,Regulator of G-protein Signaling,RGS Protein,CCG-50014,inhibit,CCG50014,Inhibitor
- CCG-50014, 10 mM in DMSO
- 883050-24-6
- Inhibitors
