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AdipoRon

AdipoRon Struktur
924416-43-3
CAS-Nr.
924416-43-3
Englisch Name:
AdipoRon
Synonyma:
SC-396658;CS-918;104890;AdipoRon;AdipiRon;AdipoR agonist;AdipoRon (SC-396658);AdipoRon, 10 mM in DMSO;AdipoR Agonist, AdipoRon;924416-43-3, CFCD924416433,
CBNumber:
CB82681793
Summenformel:
C27H28N2O3
Molgewicht:
428.52
MOL-Datei:
924416-43-3.mol

AdipoRon Eigenschaften

Schmelzpunkt:
106-108°C
Siedepunkt:
645.3±55.0 °C(Predicted)
Dichte
1.21±0.1 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: soluble10mg/mL, clear
pka
13.92±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI
InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
InChIKey
SHHUPGSHGSNPDB-UHFFFAOYSA-N
SMILES
C(NC1CCN(CC2=CC=CC=C2)CC1)(=O)COC1=CC=C(C(=O)C2=CC=CC=C2)C=C1
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,N
R-S?tze: 22-50/53
S-S?tze: 60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)Environment (GHS09)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

AdipoRon Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 μM, respectively. At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-fat diet and in genetically obese db/db mice.

Biochem/physiol Actions

AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.

Clinical claims and research

AdipoRon is a small, synthetic molecule that binds both adiponectin receptors AdipoR1 and AdipoR2 with a Kd of approximately 1.8 and 3.1 mM, respectively. This synthetic adiponectin receptor agonist exhibits strong anti-obesity, anti-diabetic, anti-depressant, anti-ischemic, and anti-hypertrophic activities. AdipoRon behaves similarly to adiponectin in muscle and liver tissues of mice that are fed a high-fat diet, reducing insulin resistance and glucose intolerance through activation of the AMPK and PPAR-α pathways. Clinically, AdipoRon can be used to improve post-traumatic stress disorder, anxiety, and systemic sclerosis; it is being evaluated for the treatment of several forms of cancer, including pancreatic ductal adenocarcinoma, myeloma, breast, and ovarian cancer. Treatment of myeloma cell lines with AdipoRon significantly induced expression of the apoptosis-related proteins cleaved caspase-3 and cleaved PARP, and inhibited cell proliferation. A study using a mouse model of hypertension indicated that this AdipoRon treatment could prevent renal fibrosis in hypertensive patients.

AdipoRon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AdipoRon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 161)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Scibiotron Pharmaceutical Co., Ltd
+86-16621589600
contact@scibiotron.com China 5783 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5745 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
+86-86-22-87899925 +86-8618522618860
18522618860@163.com China 694 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Chemia Biotechnology(Shanghai) Co., Ltd
+8613816753574
info@chemia-pharm.com CHINA 311 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471;
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58

924416-43-3()Verwandte Suche:


  • AdipoRon
  • 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetaMide
  • 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
  • 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide AdipoRon
  • AdipoR agonist
  • AdipiRon
  • ACETAMIDE, 2-(4-BENZOYLPHENOXY)-N-[1-(PHENYLMETHYL)-4-PIPERIDINYL]-
  • 104890
  • CS-918
  • 924416-43-3, CFCD924416433,
  • AdipoRon (SC-396658)
  • AdipoRon, Adiponectin receptor agonist
  • AdipoRon, 10 mM in DMSO
  • AdipoR Agonist, AdipoRon
  • SC-396658
  • 924416-43-3
  • Inhibitors
  • API
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