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2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Struktur
305834-79-1
CAS-Nr.
305834-79-1
Englisch Name:
2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester
Synonyma:
SC79;SC97;CS-2177;SC79;SC 79;Akt Activator II;SC79, Akt activator;SC79, 10 mM in DMSO;Akt Activator II, SC79;SC79;SC 79;AKT ACTIVATOR II;Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem
CBNumber:
CB82708757
Summenformel:
C17H17ClN2O5
Molgewicht:
364.78
MOL-Datei:
305834-79-1.mol

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Eigenschaften

Siedepunkt:
524.8±50.0 °C(Predicted)
Dichte
1.340±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO: soluble20mg/mL, clear
pka
3.03±0.40(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI
1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3
InChIKey
DXVKFBGVVRSOLI-UHFFFAOYSA-N
SMILES
Clc1cc2c(cc1)OC(=C(C2C(C(=O)OCC)C#N)C(=O)OCC)N

Sicherheit

WGK Germany  3
HS Code  2932990090
Speicherklasse 11 - Combustible Solids

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. For example, both Thr308 and Ser473 on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 μg/ml). SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling. SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.

Verwenden

SC79 has been used in western blot analysis as a positive control to measure the extent of phosphorylation of Akt and also to activate Akt that has been suppressed by nitidine chloride, a natural bioactive alkaloid.

Allgemeine Beschreibung

A cell-permeable and blood-brain barrier permeant bromo-to-chloro substituted HA14-1 (Cat. No. 371971) analog that renders Akt in a conformation susceptible to phosphorylation by upstream kinases via specific interaction with Akt pleckstrin homology (PH) domain PtdIns(3,4,5)P3- (PIP3) binding pocket. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473) in a time- and dose-dependent manner (2 to 4 μg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 μg/ml) in vitro and in a murine MCAO (middle cerebral artery occlusion) model (40 mg/kg, i.p.) in vivo.

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 167)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20111 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32998 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29766 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 963 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413
contact@trustwe.com China 5742 58
TargetMol Chemicals Inc.
+1-781-999-5354; +1-00000000000
marketing@targetmol.com United States 32431 58
Finetech Industry Limited
+86-27-8746-5837 +86-18627785180
info@finetechnology-ind.com China 9539 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6378 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49709 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11674 58

305834-79-1()Verwandte Suche:


  • 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester
  • 2-Amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
  • Akt Activator II, SC79
  • Akt Activator II
  • SC79;SC 79;AKT ACTIVATOR II
  • 4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester
  • SC79;SC 79
  • Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem
  • CS-2177
  • Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4Hchromene-3-carboxylat
  • SC97
  • Ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
  • SC79,inhibit,Akt,Protein kinase B,Inhibitor,SC-79,PKB
  • SC79, Akt activator
  • SC79, 10 mM in DMSO
  • 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester, CAS 305834-79-1
  • 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester
  • Ethyl 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate
  • SC79
  • 305834-79-1
  • Inhibitors
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