6(S)-Lipoxin A4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-
conjugated tetraene. Lipoxin A
4 (LXA
4) was first described as a metabolite of 15-
HpETE and/or 15-
HETE when added
in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S), 6(R); and the 11-
trans and 11-
cis isomers of each of these. 6(S)-
LXA
4 is one of the original four metabolites first identified by Serhan, Nicolaou, and Samuelsson. It was considered to be an artifact by these authors because it lacked the potency of the 5(S),6(R) isomer with respect to contraction of isolated guinea pig lung parenchymal strips. It has not been possible to isolate “natural” LXA
4 from humans or other mammals in amounts sufficient for determination of absolute stereochemistry. Most authors refer to LXA
4 as the 5(S),6(R), 11-
cis isomer, but it is not clear that biological systems are aware of or agree with these conventions. Historically, conjugated tetraenes flanked by hydroxyl groups of mixed stereochemistry have been marketed as ''Lipoxin A
4'' by some biomolecular supply companies. The availability of single pure LXA
4 enantiomers should help to reduce the confusion this has caused.
6(S)-Lipoxin A4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
