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MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28)

MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Struktur
CAS-Nr.
Englisch Name:
MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28)
Synonyma:
Monoclonal Anti-H3S28p;MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28);Monoclonal Anti-phospho-Histone H3 (pSer28) antibody produced in rat
CBNumber:
CB8334505
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Eigenschaften

storage temp. 
−20°C
Aggregatzustand
buffered aqueous solution
Biologische Quelle
rat

Sicherheit

WGK Germany  -

MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-phospho-Histone H3 (pSer28) antibody is suitable for immunoblotting (approx. 15 kDa), immunocytochemistry (3.7% formaldehyde-methanol fixation) and flow cytometry applications.

Allgemeine Beschreibung

Histone H1 and the N-terminal tail of histone-3 (H3) have key roles in the folding and inter-association of the chromatin fibers. Two currently known phosphorylation sites are present in the N-terminus of H3; serine-10 and serine-28. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.

Biochem/physiol Actions

Mitogenic stimulation, oncogenic transformation, or induction of oncogenic ras expression are accompanied with increase in serine-10 phosphorylation of the H3 N-terminal domain. It has been shown that phosphorylated H3 is associated with c-fos and c-myc genes in stimulated cells. Phosphorylation of H3, at both serine-10 and -28, coincides with the induction of mitotic chromosome condensation.H3 phosphorylation may contribute to proto-oncogene induction by modulating chromatin structure and releasing blocks in elongation. H3 dephosphorylation occurs quite rapidly after mitosis and serine-10/28 reo main unphosphorylated throughout the remainder of interphase. PP1 has been identified as the H3 phosphatase.

MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 3)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51395 80

  • Monoclonal Anti-phospho-Histone H3 (pSer28) antibody produced in rat
  • MONOCLONAL ANTI-PHOSPHO-HISTONE H3 (PSER28)
  • Monoclonal Anti-H3S28p
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