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Hirudin

HIRUDIN Struktur
8001-27-2
CAS-Nr.
8001-27-2
Bezeichnung:
Hirudin
Englisch Name:
HIRUDIN
Synonyma:
hirudex;NATIVE HIRUDIN;DESULFO-HIRUDIN;DESULFATO-HIRUDIN;recombinanthirudin;HIRUDIN RECOMBINANT;hirudin from leeches;[TYR63]HIRUDIN (HV1), LEECH;Hirudin recombinant from yeast;[63-TYROSINE]HIRUDIN (HV1), LEECH
CBNumber:
CB8399669
Summenformel:
C287H440N80O113S7
Molgewicht:
7043.4877
MOL-Datei:
8001-27-2.mol

Hirudin Eigenschaften

storage temp. 
2-8°C
L?slichkeit
0.1 M Tris, 0.2 M NaCl, pH 8.4: 1vial/mL, clear, colorless
Aggregatzustand
lyophilized powder
Farbe
white
Biologische Quelle
synthetic
yeast (Pichia pastoris)
Wasserl?slichkeit
pyridine: soluble
water: soluble
Merck 
13,4737
Specific Activity
≥7,000ATU/mg protein (ATU = antithrombin units)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  3
RTECS-Nr. MR8440000
10-21
HS Code  3504009000
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)Health Hazard (GHS08)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung P261, P285, P304+P341, P342+P311,P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Hirudin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Refludan was launched in Germany for heparin-associated thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis), the gene for recombinant hirudin was synthesized and expressed in Saccharomyces cerevisiae. The isolated protein is 65 amino acids differing from the native protein by the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain the three disulfide bonds. Refludan is a potent, specific and almost irreversible inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds to the active catalytic site of thrombin, while the C-terminal end binds to the anion binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is a pure, single compound with a single mechanism of action. It is useful for myocardial infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited by platelets activated by the Fc fragment of antibodies developed to the antigen of heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.

Verwenden

Recombinant hirudin from yeast has been used in mannan-binding lectin serine protease 2 (MASP2) activation assay. It has also been used in pre-treating the nanosheets in phosphate buffered saline (PBS) for platelet adhesion assay.

Allgemeine Beschreibung

Hirudin is a 7 kDa acidic protein containing 65 amino acid residues that has an isoelectric point of 3.5-4.0. It is not glycosylated and lacks tryptophan, arginine and methionine residues. It is chemically stable between pH 2-12 and at temperatures up to 80°C.

Hirudin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Hirudin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 97)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
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+8618108235634
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+undefined18013301590
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027-88013699 17354350817
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Shaanxi LonierHerb Bio Technology Co Ltd
+86-86-+86-86-029-87551862 +8617702909819
1713330907@QQ.com China 2639 58
Watson Biotechnology Co.,Ltd
+86-18186686046 +86-18186686046;
sales01@watsonbiotech.cn China 5733 58

8001-27-2(Hirudin)Verwandte Suche:


  • hirudex
  • recombinanthirudin
  • HIRUDIN RECOMBINANT
  • DESULFATO-HIRUDIN
  • DESULFO-HIRUDIN
  • NATIVE HIRUDIN
  • [TYR63]HIRUDIN (HV1), LEECH
  • (63-tyrosine)hirudin (hv1),leech,rec. F. yeast
  • [Tyr63]Hirudin (HV1), leech recombinant, from yeast
  • hirudin from leeches
  • Hirudin recombinant from yeast
  • Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces Cere
  • [63-tyrosine]hirudin (HV1), leech recombinant
  • [63-TYROSINE]HIRUDIN (HV1), LEECH
  • [63-Tyrosine]Hirudin (HV1), leech, Desulfato-hirudin, Desulfo-hirudin
  • Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces cerevisiae - CAS 8001-27-2 - Calbiochem
  • 8001-27-2
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • R to Z
  • Proteins
  • Biochemicals and Reagents
  • BioChemical
  • Coagulation Proteins and ReagentsPlasma&Blood Proteins
  • HirudinProtease Inhibitors
  • Plasma&Blood Proteins
  • Plasma, Blood, and Related Proteins and Reagents
  • Protease Inhibitor Specificity Index
  • Proteins and Derivatives
  • R to
  • Thrombin
  • ThrombinEnzyme Inhibitors by Enzyme
  • proteins
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