Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
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- CAS-Nr.
- 486460-00-8
- Englisch Name:
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
- Synonyma:
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid;BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID;(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid;3(R)-tert-ButoxycarbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid;(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID;(3R)-N-Boc-3-amin;BOC- Butanoic Acid;Parecoxib SodiuM API
- CBNumber:
- CB8402112
- Summenformel:
- C15H18F3NO4
- Molgewicht:
- 333.31
- MOL-Datei:
- 486460-00-8.mol
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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Eigenschaften
- Schmelzpunkt:
- 136-138℃
- Siedepunkt:
- 443.1±45.0 °C(Predicted)
- Dichte
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 4.30±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Optische Rotation
- 25.305°(C=0.01g/ mI, CHCL3 , 20°C, 589nm)
- InChI
- InChI=1/C15H18F3NO4/c1-15(2,3)23-14(22)19-9(6-13(20)21)4-8-5-11(17)12(18)7-10(8)16/h5,7,9H,4,6H2,1-3H3,(H,19,22)(H,20,21)/t9-/s3
- InChIKey
- TUAXCHGULMWHIO-DJEYLCQNNA-N
- SMILES
- C(C1C=C(F)C(F)=CC=1F)[C@H](CC(=O)O)NC(=O)OC(C)(C)C |&1:10,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.
Verwenden
(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.
Synthese
(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 406)Lieferanten
486460-00-8()Verwandte Suche:
- Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-
- (R)-Sitagliptin N-Boc-Acid IMpurity
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%
- (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
- (3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl)
butanoic acid (BOC acid)
- [[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta
- (R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid
- Sitagliptin Intermediate 1
- [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid
- (3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU
- (3R)-3-(1,1-Dimethylethoxy carbonyl) amino]- 4-(2,4,5-trifluorophenyl) butanoic acid
- Sitagliptin interMediate
- (R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic
- (3R)-3-((1,1-DIMETHYLETHOXYCARBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID
- (R)-3-(Boc-aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
- 4-(6-{[(tert-butoxy)carbonyl]aMino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid
- Parecoxib SodiuM API
- Sitagliptin interMediateB
- (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
- Sitagliptin impurity 19/(R)-Sitagliptin N-Boc-Acid Impurity/(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
- Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)
- Sitagliptin Acid Boc Impurity (Impurity A)
- BOC- Butanoic Acid
- BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY
- Sitagliptin Impurity 78
- Sitagliptin N-BOC Carboxylic acid Impurity
- (Tert-Butoxy)Carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid
- Sitagliptin Impurity 19
- (3R)-N-Boc-3-amin
- (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]
- Sitagliptin N-BOC Carboxylic Acid
- Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
- Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci
- BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH
- Sitagliptin EP Impurity 15
- 5-TRIFLUORO-PHENYL)-BUTYRIC ACID
- BOC-(R)-3-AMINO-4-(2
- N-Boc Sitagliptin Acid Impurity
- Sitagliptin Imp-1(sitagliptin Impurity-A)
- [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be...
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
- (R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid
- (R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid
- Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate
- (βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid
- Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid)
- (3R) - N - (tert butoxycarbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid
- BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid
- Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid
- 4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione
- Sitagliptin Impurity 19
(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid
- (3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-(2,4,5-trifluorophenyl) butanoic acid
- (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid (Intermediate of Sitagliptin phosphate)
- (R)-3-(Boc-amino)-4-(2,4,5-trifluorophenyl)butyric Acid
- (3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID
- (R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
- 3(R)-tert-ButoxycarbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid
