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5-(N,N-HEXAMETHYLENE)-AMILORIDE

5-(N,N-HEXAMETHYLENE)-AMILORIDE Struktur
1428-95-1
CAS-Nr.
1428-95-1
Englisch Name:
5-(N,N-HEXAMETHYLENE)-AMILORIDE
Synonyma:
hma;Amilo;5-HMA;HMA-5;amipromizide;Hexamethyleneamiloride;5-(N,N-HEXAMETHYLENE)-AMILORIDE;AMILORIDE,5-(N,N-HEXAMETHYLENE)-;HMA (5-(N,N-Hexamethylene)amiloride);5-(N,N-HEXAMETHYLENE)-AMILORIDE USP/EP/BP
CBNumber:
CB8418632
Summenformel:
C12H18ClN7O
Molgewicht:
311.77
MOL-Datei:
1428-95-1.mol

5-(N,N-HEXAMETHYLENE)-AMILORIDE Eigenschaften

Schmelzpunkt:
224-225 °C
Dichte
1.63±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMF: 3mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
Aggregatzustand
A crystalline solid
pka
8.81±0.46(Predicted)
Farbe
Light yellow to yellow
InChI
1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21)
InChIKey
RQQJJXVETXFINY-UHFFFAOYSA-N
SMILES
N\C(N)=N\C(=O)c1nc(Cl)c(nc1N)N2CCCCCC2

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 23/24/25
S-S?tze: 22-36/37/39-45
RIDADR  2811
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral

5-(N,N-HEXAMETHYLENE)-AMILORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride with diverse biological activities. It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 μM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 μM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 μM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 μM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.

Definition

ChEBI: A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.

Biochem/physiol Actions

Inhibitor of Na+/H+ antiport.

5-(N,N-HEXAMETHYLENE)-AMILORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5-(N,N-HEXAMETHYLENE)-AMILORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 67)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com CHINA 954 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 20584 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39039 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+86-18621343501; +undefined18621343501
product@acmec-e.com China 33324 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
+8618950047208
ellena@amitychem.com China 43414 58

1428-95-1()Verwandte Suche:


  • 5-(N,N-HEXAMETHYLENE)-AMILORIDE
  • AMILORIDE,5-(N,N-HEXAMETHYLENE)-
  • 3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-(HEXAHYDRO-1H-AZEPIN-1-YL)-PYRAZINE-CARBOXAMIDE
  • AMILORIDE, 5-(N,N-HEXAMETHYLENE) >93% NA +/H+ ANTIPORTER INH
  • amipromizide
  • 3-Amino-5-(1-azacycloheptane-1-yl)-6-chloro-N-(aminoiminomethyl)pyrazine-2-carboxamide
  • 3-Amino-5-(hexahydro-1H-azepin-1-yl)-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide
  • 6-Chloro-3-amino-5-[(hexahydro-1H-azepin)-1-yl]-N-(diaminomethylene)-2-pyrazinecarboxamide
  • Hexamethyleneamiloride
  • N-(Diaminomethylene)-3-amino-5-(hexamethyleneamino)-6-chloropyrazine-2-carboxamide
  • 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylene)pyrazinamide
  • 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
  • 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloro-pyrazine-2-carboxamide
  • HMA (5-(N,N-Hexamethylene)amiloride)
  • 5-(N,N-Hexamethylene)amiloride Solution, 100ppm
  • Amilo
  • 5-HMA
  • HMA-5
  • 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-(hexahydro-1H-azepin-1-yl)-
  • 5-(N,N-HEXAMETHYLENE)-AMILORIDE USP/EP/BP
  • hma
  • 1428-95-1
  • C12H18ClN7O
  • BioChemical
  • Monovalent Ion Channels
  • Ion Channels
  • Sodium Channel Modulators
  • Voltage-gated Ion Channels
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Amiloride and Derivatives
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