(2-Hydroxypropyl)-γ-cyclodextrin
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- CAS-Nr.
- 128446-34-4
- Englisch Name:
- (2-Hydroxypropyl)-γ-cyclodextrin
- Synonyma:
- 2-FLUORO-4-METHYL-1-NITROBENZENE;HP-γ-CD;HP-γ-Cyclodextrin;Hydroxypropyl-γ-Cyclodextrin;HPGCD;HP-gamma-CD;CAVASOL(R)W8;Cavasol? W8 HP;Calcium Dobesilate Capsules;HYDROXYPROPYL-Y-CYCLODEXTRIN
- CBNumber:
- CB8449476
- Summenformel:
- C48H80-nO40.(C3H7O)n
- Molgewicht:
- 0
- MOL-Datei:
- 128446-34-4.mol
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(2-Hydroxypropyl)-γ-cyclodextrin Eigenschaften
- Schmelzpunkt:
- 52-55 °C(lit.)
- Siedepunkt:
- 97-98 °C3 mm Hg(lit.)
- Flammpunkt:
- >230 °F
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: soluble450mg/mL
- Aggregatzustand
- Solid powder
- Farbe
- white
- PH
- 6-9 (2% in H2O)
- Optische Rotation
- [α]20/D +145°, c = 1 in H2O
- InChIKey
- WZMOWQCNPFDWPA-UHFFFAOYSA-N
- CAS Datenbank
- 128446-34-4(CAS DataBase Reference)
- Absorption
- ≤1.7 at 220-350nm in solution at 2%
≤1.7 at 350-660nm in solution at 2%
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
20/21/22-36/37/38 |
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| S-S?tze: |
26-36/37 |
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| WGK Germany |
3 |
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| HS Code |
2940000080 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(2-Hydroxypropyl)-γ-cyclodextrin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
white powder
Verwenden
For R&D use
Allgemeine Beschreibung
(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.
Biologische Aktivit?t
(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. HPγCD treatment promotes a wide distribution of lysosomes across the cytoplasm in NPC1 patient-derived fibroblasts. In contrast, lysosomes are clustered near the cell center in untreated cells, raising the possibility that HPγCD has the potential to modulate lysosomal dynamics and functions[1]. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation. Industrially produced HPγCD, which is used as a complexing agent in new ophthalmic formulations, is not a single compound but a heterogeneous, complex mixture of homologues and isomers substituted by a variable number of 2-hydroxy-propyl groups at different positions of the sugar moieties[2].
(2-Hydroxypropyl)-γ-cyclodextrin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(2-Hydroxypropyl)-γ-cyclodextrin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 221)Lieferanten
128446-34-4()Verwandte Suche:
- g-Cyclodextrin, 2-hydroxypropylethers
- Cavasol? W8 HP
- (2-Hydroxypropyl)-gamma-cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany
- (2-Hydroxypropyl)-gamma-cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, >=98.0% (HPLC)
- (2-Hydroxypropyl)-gaMMa-cyclodextrin extent of labeling: 0.6 Molar substitution
- HYDROXYPROPYL-GAMMA-CYCLODEXTRIN (HGC) 4 5% W/V SOLUTION IN H2O
- HYDROXYPROPYL-GAMMA-CYCLODEXTRIN, MS=0.6
- .gamma.-Cyclodextrin, 2-hydroxypropyl ethers
- CAVASOL(R)W8
- (2-Hydroxypropyl)-γ-cyclodextrin,HGC
- (2-Hydroxypropyl)-gamma-cyclodextrinsolid
- (2-Hydroxyapropyl)-gamma-cyclodextrin
- HP-gamma-CD
- HPGCD
- (2-Hydroxypropyl)-γ-cyclodextrin (Technical Grade)
- Hydroxypropyl-Gamma-Cyclodextrin with good quality and stable supply
- (2-Hydroxypropyl)-gamma-cyclodextrin,average Mw ~1，589
- HydroxypropyI Gamma Cyclodextrin
- γ-Cyclodextrin, 2-hydroxypropyl ethers
- Calcium Dobesilate Capsules
- (2-hydroxypropyl)-γ-cyclodextrin
- (2-Hydroxypropyl)-gamma-cyclodextrin (Technical Grade)
- (2-Hydroxypropyl)-gamma-cyclodextrin (DS~4.5)
- HYDROXYPROPYL-Y-CYCLODEXTRIN
- 2-FLUORO-4-METHYL-1-NITROBENZENE
- HP-γ-CD
- HP-γ-Cyclodextrin
- Hydroxypropyl-γ-Cyclodextrin
- 128446-34-4
- C63H110O45
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