THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC₅₀s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD	13816107857	sales@fortunechem-sh.com	China	981	58
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9642	58
Changzhou Chenhong Biotechnology Co., Ltd.	+86-0519-85788828 +86-13775037613	sales@chemrenpharm.com	China	4061	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Shanghai Universal Biotech Co.,Ltd	15921930842 15921930842	yh-wang@univ-bio.com	China	25022	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11972	58
Shanghai Lingfei Pharmaceutical Technology Co., Ltd	15618928656	771909552@qq.com	China	1265	58
Cayman Chemical Company	--	sales@caymanchem.com	China	6838	58

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• THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
• TR ANTAGONIST 1-850
• 2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE
• 1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea
• Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
• 251310-57-3
• C21H20F3N5O4