1,3,4,5-TETRAHYDRO-PYRANO[4,3-B]INDOLE Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
The synthesis method of 1,3,4,5-TETRAHYDRO-PYRANO[4,3-B]INDOLE is as follows: Bubble argon to a suspension of 2-chloroaniline (208.1 mg, 1.63 mmol), tetrahydropyran-4-one (477.3 mg, 4.77 mmol), acetic acid (0.14 mL, 2.45 mmol) and magnesium sulfate (116.7 mg, 0.97 mmol) in dimethylacetamide (3.0 mL) for 10 minutes; Add tripotassium phosphate (437.7 mg, 2.06 mmol) and [Pd (tBu3P)2] (84.1 mg, 0.16 mmol); Bubble argon through the mixture for an additional 5 minutes; Heat the reaction mixture for 2 hours at 140 °C in a sealed tube; Cool the mixture to room temperature and filter; Add water (10 mL) to the filtrate and extract with ethyl acetate (3 x 20 mL); Dry the combined organic layers over magnesium sulfate, filter and concentrate in vacuo; Purify by flash chromatography (n-hexane/EtOAc 80/20).
Einzelnachweise
[1]Géraldy M, Morgen M, Sehr P, Steimbach RR, Moi D, Ridinger J, Oehme I, Witt O, Malz M, Nogueira MS, Koch O, Gunkel N, Miller AK. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019 May 9;62(9):4426-4443. doi: 10.1021/acs.jmedchem.8b01936.
1,3,4,5-TETRAHYDRO-PYRANO[4,3-B]INDOLE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
