PF-06873600

2185857-97-8

CAS-Nr.: 2185857-97-8

Englisch Name:: PF-06873600

Synonyma:: Ebvaciclib;PF-06873600;PF06873600,PF 06873600;Ebvaciclib (PF-06873600);PF-06873600, 10 mM in DMSO;6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）

CBNumber:: CB84918288

Summenformel:: C20H27F2N5O4S

Molgewicht:: 471.52

MOL-Datei:: 2185857-97-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 100

PF-06873600 Eigenschaften

Siedepunkt:: 634.0±65.0 °C(Predicted)

Dichte: 1.47±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

L?slichkeit: DMSO:15.0(Max Conc. mg/mL);31.81(Max Conc. mM)

Aggregatzustand: A solid

pka: 14.69±0.40(Predicted)

Farbe: White to light yellow

InChIKey: QIEKHLDZKRQLLN-FOIQADDNSA-N

SMILES: C1(NC2CCN(S(C)(=O)=O)CC2)=NC=C2C=C(C(F)F)C(=O)N([C@@H]3CCC[C@]3(O)C)C2=N1

Sicherheit

PF-06873600 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6 with Ki values of 0.1, 1.2, and 0.1 nM, respectively. It also blocks the phosphorylation of retinoblastoma protein (RB1) and limits the proliferation of OVCAR-3 ovarian cancer cells with EC50s of 19 and 45 nM, respectively.

PF-06873600 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PF-06873600 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 100)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Jiangsu Nata Opto-electronic Material Co.,Ltd.	+86-0512-62520998 +86-15030927757	gaoym@natachem.com	China	229	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9946	58

PF-06873600
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]（PF-06873600）
6-(Difluoromethyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
Ebvaciclib (PF-06873600)
PF06873600,PF 06873600
PF-06873600, 10 mM in DMSO
Ebvaciclib
2185857-97-8
C20H27F2N5O4S

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