Azasetron hydrochloride
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- CAS-Nr.
- 123040-16-4
- Englisch Name:
- Azasetron hydrochloride
- Synonyma:
- AZASETRON;Serotone;Y-25130;Y-25130HCl;AZASETRON HCL;PubChem CID 2264;Y-25130 HYDROCHLORIDE;Azasetron hydrochloride;Azasetron HCl (Y-25130);Azasetron hydrochloride
- CBNumber:
- CB8706748
- Summenformel:
- C17H20ClN3O3.ClH
- Molgewicht:
- 386.27
- MOL-Datei:
- 123040-16-4.mol
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Azasetron hydrochloride Eigenschaften
- Schmelzpunkt:
- 281° (dec); mp 305° (dec) (Kawakita)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- White solid.
- Farbe
- White
- Wasserl?slichkeit
- H2O: 2mg/mL, clear
- InChI
- InChI=1/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1H
- InChIKey
- DBMKBKPJYAHLQP-UHFFFAOYNA-N
- SMILES
- C12OCC(=O)N(C)C=1C=C(Cl)C=C2C(=O)NC1CN2CC[C@]1([H])CC2.Cl |&1:21,r|
- CAS Datenbank
- 123040-16-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Toxizit?t |
LD50 in male, female rats (mg/kg): 135, 132 i.v. (Takagi) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Azasetron hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nazasetron (azasetron) hydrochloride is the fourth in the class of highly potent 5-
HT
3 receptor antagonists to reach the market for prophylaxis of severe nausea and
vomiting induced by cytotoxic chemotherapy and by total body X-radiation. In a
study with 146 cancer patients suffering from emesis induced by cisplatin,
nazasetron was reported to be markedly effective in 72% of subjects. Nazasetron is
devoid of dopamine D
2 receptor blocking activity and therefore is free of the
extrapyrimidal side effects associated with other commonly used antiemetics such
as metoclopramide and domperidone. Nazasetron has been reported to be
potentially useful for the treatment of gastrointestinal motility dysfunction, such as
gastric stasis, vomiting and irritable bowel syndrome.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
Biologische Aktivit?t
A selective and potent 5-HT 3 antagonist (K i = 2.9 nM).
Azasetron hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Azasetron hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 200)Lieferanten
123040-16-4()Verwandte Suche:
- N-(1-Azabicyclo[2.2.2]octane-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide·hydrochloride
- 6-chloro-3-keto-4-methyl-N-quinuclidin-3-yl-1,4-benzoxazine-8-carboxamide hydrochloride
- N-{1-azabicyclo[2.2.2]octan-3-yl}-6-chloro-4-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxaMide
- Azastron hydrochloride injection
- N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxaMide hydrochloride (1:1)
- N-1-AZABICYCLO[2.2.2]-OCT-3-YL-6-CHLORO-3,4-DIHYDRO-4-METHYL-3-OXO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE, HYDROCHLORIDE
- N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HCL
- N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HYDROCHLORIDE
- Y-25130 HYDROCHLORIDE
- Y-25130
- 2h-1,4-benzoxazine-8-carboxamide,3,4-dihydro-n-1-azabicyclo(2.2.2)oct-3-yl-6-c
- N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide, hydrochloride (1:1)
- AZASETRON HCL
- N-(1-Azabicyclo[2,2,2]Oct-3-Yl)-6-Chloro-4-Methyl-3-Oxo-3,4-Dihydro-2h-1,4-Benzoxazine-8-Carboxamide HCl
- Y-25130HCl
- N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzo
- INTERMEDIATE OF AZASETRON HCL
- Azasetron hydrochloride
- N-(1-Azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride
- N-[(3S)-1-azoniabicyclo[2.2.2]octan-3-yl]-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide
- Azasetron hydrochloride , CID 115000
- PubChem CID 2264
- Azasetron HCl (Y-25130)
- N-{1-azabicyclo[2.2.2]octan-3-yl}-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
- 6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide hydrochloride
- Azasetron hydrochloride
- Azasetron hydrochloride
- 6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-carboxamide hydrochloride
- AZASETRON
- Serotone
- Azasetron dihydrochloride
- 123040-16-4
- C17H21Cl2N3O3
- Serotonin receptor
- anti-emetic
