CARNOSOL

5957-80-2

CAS-Nr.: 5957-80-2

Englisch Name:: CARNOSOL

Synonyma:: carnol;CARNOSOL;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol (Standard);Carnosol, 10 mM in DMSO;Carnosol(P)(Request Quote);Carnosol, froM RoseMarinus officinalis

CBNumber:: CB8736565

Summenformel:: C20H26O4

Molgewicht:: 330.42

MOL-Datei:: 5957-80-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 256

CARNOSOL Eigenschaften

Schmelzpunkt:: 240～242℃

Siedepunkt:: 524.8±50.0 °C(Predicted)

Dichte: 1.26±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Store in freezer, under -20°C

L?slichkeit: DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)

pka: 8.91±0.40(Predicted)

Aggregatzustand: Solid

Farbe: White

Biologische Quelle: Rosemarinus officinalis L. leaves

Major Application: food and beverages

InChI: InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1

InChIKey: XUSYGBPHQBWGAD-PJSUUKDQSA-N

SMILES: C1(C)(C)[C@@]2([H])[C@]3(C(=O)O[C@@]([H])(C2)C2=C3C(O)=C(O)C(C(C)C)=C2)CCC1

LogP: 2.832 (est)

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

S-S?tze:	24/25
WGK Germany	3
HS Code	29322090
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Skin Sens. 1
Giftige Stoffe Daten	5957-80-2(Hazardous Substances Data)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H317	Kann allergische Hautreaktionen verursachen.	Sensibilisierung der Haut	Kategorie 1A	Warnung		P261, P272, P280, P302+P352,P333+P313, P321, P363, P501

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352	BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

CARNOSOL Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC₅₀ = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC₅₀ = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.

Chemische Eigenschaften

White powder

Verwenden

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

Cytotoxicity

IC₅₀ (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC₅₀ (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC₅₀ (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC₅₀ (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).

CARNOSOL Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

EPIROSMANOL Rosmanol

CARNOSOL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 256)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	477	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	4616	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58

5957-80-2()Verwandte Suche:

2-(4-Isopropylphenyl)propionaldehyd Cyclomenol 1-Phenylcyclohexan-1-carbonsure Tetrahydro-3-pentyl-2H-pyran-2-on Ethyl-4-isopropylphenylacetat (1-Phenylcyclohexan)methanol

1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE
CARNOSOL(RG)
CARNOSOL
Carnosol, froM RoseMarinus officinalis
Carnosol, 98%, from Rosemarinus officinalis
2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
CARNOSOL USP/EP/BP
(4aR,9S,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydro-1H-9,4a-(epoxymethano)phenanthren-12-one
D-α-Alanine
carnol
(5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
Carnosol(P)(Request Quote)
Carnosol-RM
Carnosol, 10 mM in DMSO
Carnosol (Standard)
5957-80-2
chemical reagent
pharmaceutical intermediate
Miscellaneous Natural Products
Antioxidant
Biochemicals Found in Plants
Nutrition Research
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract

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