Ceramide Chemische Eigenschaften,Einsatz,Produktion Methoden
benefits
Ceramides are lipids, which are fatty acids that are produced in the sebaceous glands. Ceramides help to moisturise and strengthen the protective skin moisture barrier, and protect the skin from external aggressors such as weather and pollution.
Mode of action
Topically applied ceramide (Cer) could improve barrier function in three possible ways: (1) Cer in an appropriate formulation constructs (lamellar) liquid crystalline and/or gel structures; (2) Cer is likely incorporated into lamellar bilayer structures in the SC to repair incompetent bilayer structures; and/or (3) Cer penetrates into nucleated layers of the epidermis and becomes a precursor to endogenous Cer synthesis following hydrolysis to the sphingoid base and FA. In addition, Cer absorbed into nucleated layers of the epidermis could suppress KC proliferation and promote differentiation. Because Cer production is increased during KC differentiation, the stimulation of KC differentiation can increase de novo Cer production, thereby contributing to barrier formation[1].
Synthese
Because of its crucial importance as a major constituent of biological membranes, several synthetic approaches to the optically active ceramide 1, the hydrophobic part of the sphingolipids, have recently been reported. A practical and an efficient route for the D-erythro ceramide 1 could be developed in a stereo-controlled way using D-glucose as a starting material. As a practical and an efficient route for the synthesis of ceramide 1 based on an 11-step conversion of 1,2,5,6-di-O-isopropylidene-oz-D-glucofu ranoside 2 into D-erythro-ceramide 1 in an overall yield of about 20% (the yields are not optimised).
Ceramide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
