Natriumhydroxymethansulfinat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white solid; used as stripping and discharge agent for textiles [HAW93]
Verwenden
Pharmaceutic aid (preservative).
Vorbereitung Methode
Sodium formaldehyde sulfoxylate is manufactured from sodium
dithionate and formaldehyde in water.
Pharmazeutische Anwendungen
Sodium formaldehyde sulfoxylate is a water-soluble antioxidant
and is generally used as the dihydrate. It is used in the formulation
of injection products at a level of up to 0.1% w/v in the final
preparation administered to the patient.
Sicherheit(Safety)
The toxicological properties of sodium formaldehyde sulfoxylate
have not been fully investigated. However, it is used in the
formulation of injection products at a level to 0.1% w/v in the
final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by
ingestion, and when heated to decomposition it emits toxic fumes
of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg
Lager
Store in well-closed, light-resistant containers at controlled room
temperature (15–30℃).
l?uterung methode
It crystallises from H2O as the dihydrate and decomposes at higher temperatures. Store it in a closed container in a cool place. It is insoluble in EtOH and Et2O and is a good reducing agent. [X-ray structure: Tuter J Chem Soc 3064 1955.] Note that this compound {HOCH2SO2Na} should not be confused with formaldehyde sodium bisulfite adduct {HOCH2SO3Na} from which it is prepared by reduction with Zn. [Beilstein 1 IV 3052.]
Inkompatibilit?ten
Sodium formaldehyde sulfoxylate is incompatible with strong
oxidizing agents; it is decomposed by dilute acid.
Regulatory Status
Included in the FDA Inactive Ingredients Database (parenteral
products up to 0.1% via the IM, IV, and SC routes). Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
Natriumhydroxymethansulfinat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,2,2-Trifluorethandiol
1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-Heptadecafluoroctan
