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9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate

9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione  21-(9Z,12Z)-octadeca-9,12-dienoate Struktur
39026-39-6
CAS-Nr.
39026-39-6
Englisch Name:
9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate
Synonyma:
DXM-21-linoleate;dexamethasone linoleate;Dexamethasone-21-linoleate;9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate;(9Z,12Z)-9,12-Octadecadienoic acid 9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl ester
CBNumber:
CB8918521
Summenformel:
C40H58FO6-
Molgewicht:
653.8833232
MOL-Datei:
39026-39-6.mol

9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Eigenschaften

Sicherheit

9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Topolyn ,I.S.F.,Italy,1979

Manufacturing Process

To a stirred solution of 9α-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna1,4-diene-3,20-dione (10g, 25.5 mmol) in 20 ml pyridine and 12 ml acetone at -10°C, a cold solution of methanesulfonyl chloride (3 ml, 38.5 mmol) in 8 ml acetone was added dropwise. The addition was completed within about 3 hours and the mixture was then left standing in the cold for a further 1 hours after which 200 ml cold water were added. The resulting precipitate was separated by filtration and washed with water to give 11.5 g (96% of theoretical yield) of dexamethasone 21-mesylate, melting point 208°C to 210°C (decomposition).
The dexamethasone 21-mesylate (11.5 g, 24.5 mmol) prepared as described was added in a nitrogen atmosphere to a stirred slurry of potassium octadecacis-9, cis-12-dienoate (7.81 g, 24.5 mmol) in 70 ml DMF. After stirring for 1 hours at 50°C and evaporating the solvent in vacuo at the same temperature, the residue was washed by slurrying it into water and was then redissolved in methylene chloride, dried and the solvent evaporated. The residue was purified by chromatography on an inactivated (10% water) silica gel column (470 g) by using an ethyl acetate/hexane mixture (7:3) to give a very good yield of an oily product.

Therapeutic Function

Topical antiinflammatory

9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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39026-39-6()Verwandte Suche:


  • 9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate
  • Dexamethasone-21-linoleate
  • DXM-21-linoleate
  • dexamethasone linoleate
  • (9Z,12Z)-9,12-Octadecadienoic acid 9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl ester
  • 39026-39-6
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