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PJ 34 hydrochloride

PJ 34 hydrochloride Struktur
344458-15-7
CAS-Nr.
344458-15-7
Englisch Name:
PJ 34 hydrochloride
Synonyma:
PI34;CS-723;PJ34 HC;PJ34(HCL);PJ 34;PJ-34;PJ34 hydrochL;PJ-34 USP/EP/BP;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ34 hydrochloride, >=98%
CBNumber:
CB8972789
Summenformel:
C17H17N3O2HCl
Molgewicht:
0
MOL-Datei:
344458-15-7.mol

PJ 34 hydrochloride Eigenschaften

storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
H2O: soluble22mg/mL
Aggregatzustand
White solid
Farbe
white to yellow
Wasserl?slichkeit
water: 5mg/mL
Sensitive 
Light Sensitive & Hygroscopic
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChI
1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
InChIKey
YCALIZUKAFUQCH-UHFFFAOYSA-N
SMILES
Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
HS Code  29339900
Speicherklasse 11 - Combustible Solids

PJ 34 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.

Allgemeine Beschreibung

A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).

Biologische Aktivit?t

Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .

PJ 34 hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PJ 34 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 163)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5742 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 20584 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471;
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8615965530500
nickzhang@hangyubiotech.com China 9949 58

344458-15-7()Verwandte Suche:


  • PJ 34 Hydrochloride
  • N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride
  • PARP Inhibitor VIII, PJ34
  • PJ-34 hydrate hydrochloride
  • AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride
  • N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide
  • N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride
  • N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride
  • 2-(DiMethylaMino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride
  • PJ34(HCL)
  • Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-, hydrochloride (1:1)
  • N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride PJ 34 hydrochloride
  • PJ 34 hydrochloride N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride
  • PJ34 hydrochloride, >=98%
  • 2-(3-(Dimethylamino)-2-oxopropyl)phenanthridin-6(5H)-one hydrochloride
  • n-(6-oxo-5,6-dihydrophenanthridin-2-yl)-(n,n-dimethylamino)acetamide hydrochloride
  • CS-723
  • PJ 34;PJ-34
  • PI34
  • 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide,hydrochloride
  • PJ34 HC
  • PJ34 hydrochL
  • (PJ-34)2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
  • PJ-34 USP/EP/BP
  • PARP Inhibitor VIII PJ-34 hydrochloride PJ-34
  • PJ34 hydrochloride, PARP-1 inhibitor
  • PJ34 hydrochloride, 10 mM in DMSO
  • 344458-15-7
  • C17H17N3O2HCl
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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