SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
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- CAS-Nr.
- 165377-44-6
- Englisch Name:
- SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- Synonyma:
- SA-4503;CS-2246;SA-4503(2HCl);Cutamesine HCl;SA 4503;SA-4503;Cutamesine 2HCl;SA4503 >=98% (HPLC);Cutamesine hydrochloride;AGY94806 dihydrochloride;SA 4503 (dihydrochloride)
- CBNumber:
- CB91011619
- Summenformel:
- C23H32N2O2.2ClH
- Molgewicht:
- 441.44
- MOL-Datei:
- 165377-44-6.mol
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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 250-252°C
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
- Aggregatzustand
- powder
- Farbe
- white to beige
- Wasserl?slichkeit
- H2O: 2mg/mL, clear
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
- InChI
- 1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
- InChIKey
- XWOXAKBQEMQMFH-UHFFFAOYSA-N
- SMILES
- COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC
Sicherheit
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
SA 4503 Dihydrochloride is a novel and selective σ1 receptor agonist.
Biochem/physiol Actions
SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding σ1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (σ2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage).
SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 125)Lieferanten
165377-44-6()Verwandte Suche:
- SA 4503 (dihydrochloride)
- Cutamesine dihydrochloride
- 1-[2-(3,4-DiMethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
- SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
- 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
- 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine hydrochloride
- SA-4503(2HCl)
- Cutamesine HCl (SA-4503 HCl)
- Cutamesine HCl
- Cutamesine hydrochloride
- SA4503; SA 4503; SA-4503; AGY94806; AGY-94806; AGY 94806; CUTAMESINE HCL; CUTAMESINE HYDROCHLORIDE
- AGY94806 dihydrochloride
- SA4503 DIHYDROCHLORIDE;AGY94806 DIHYDROCHLORIDE
- CS-2246
- SA 4503;SA-4503
- SA4503 >=98% (HPLC)
- 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazin...
- Cutamesine dihydrochloride, 10 mM in DMSO
- Cutamesine (SA4503 ) dihydrochloride
- Cutamesine dihydrochloride (SA4503 dihydrochloride
- Cutamesine 2HCl
- SA-4503
- 165377-44-6
- C23H32N2O22HCl
- C23H34Cl2N2O2
- C23H32N2O22ClH
