N-Acetylcysteine amide
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- CAS-Nr.
- 38520-57-9
- Englisch Name:
- N-Acetylcysteine amide
- Synonyma:
- N-ACETYL-L-CYSTINE;(R)-2-acetaMido-3-MercaptopropanaMide;N-acetyl-L-Cysteine amide;AD4;NACA;100951;acetylcysteinamide;N-acetylcysteine amide;N-Acetyl-L-cysteinamide;Acetylcysteine Impurity 14
- CBNumber:
- CB91092625
- Summenformel:
- C5H10N2O2S
- Molgewicht:
- 162.21
- MOL-Datei:
- 38520-57-9.mol
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N-Acetylcysteine amide Eigenschaften
- Schmelzpunkt:
- 147-149 °C(Solv: ethanol (64-17-5))
- Siedepunkt:
- 441.0±40.0 °C(Predicted)
- Dichte
- 1.226±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ≥20mg/mL
- pka
- 9.21±0.10(Predicted)
- Aggregatzustand
- lyophilized powder
- Farbe
- white to off-white
- Wasserl?slichkeit
- H2O: ≥20mg/mL
DMSO: >40mg/mL
- InChI
- InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
- InChIKey
- ZLCOWUKVVFVVKA-GDVGLLTNSA-N
- SMILES
- C(N)(=O)[C@@H](NC(C)=O)CS
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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N-Acetylcysteine amide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
N-acetylcysteine amide has been used:
- to protect retinal pigment epithelium (RPE) from oxidative stress
- to show that increased expression of cell adhesion molecule 4 (CADM4) in oligodendrocytes inhibits myelination
- to protect cells from apoptosis induced by shikonin plus erlotinib/gefitinib
- as a component in various culture media
Biochem/physiol Actions
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.
Clinical Use
N-Acetylcysteine amide has antioxidant and is often used in the preparation of Eyedrops. It has been used as a treatment for the prevention or healing of cataracts, macular degeneration, and other degenerative eye disorders.
N-Acetylcysteine amide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-Acetylcysteine amide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 149)Lieferanten
38520-57-9()Verwandte Suche:
- PropanaMide,2-(acetylaMino)-3-Mercapto-, (2R)-
- N-Acetylcysteine amide Synonyms N-Acetyl-L-cysteinamide
- (R)- 2-(Acetylamino)-3-mercapto-Propanamide
- acetylcysteinamide
- AD4
- (2R)-2-acetamido-3-sulfanylpropanamide
- NACA
- N-acetylcysteine amide
- N-Acetyl-L-cysteinamide
- 100951
- (2R)-2-(Acetylamino)-3-mercaptopropanamide
- Acetylcysteine Impurity 14
- (2S)-2-acetamido-3-sulfanylpropanamide
- Nacetylcysteine amide,N acetylcysteine amide,Reactive Oxygen Species,inhibit,N-Acetylcysteine amide,Inhibitor
- N-acetylcysteine amide, 10 mM in DMSO
- N-ethylacyl-L-cysteineaminoamide
- N-Acetylcysteine amide (NACA)
- (R)-2-acetaMido-3-MercaptopropanaMide
- N-ACETYL-L-CYSTINE
- N-acetyl-L-Cysteine amide
- 38520-57-9
- C8H14N2O5S2
