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Articaine

Articaine Struktur
23964-58-1
CAS-Nr.
23964-58-1
Englisch Name:
Articaine
Synonyma:
ARTICAINE HCL;Carticaine;Articain;Articaina;40045;atecaine;ARTICAINE;Articainum;Unii-D3sq406G9x;Articaine (USP)
CBNumber:
CB9115297
Summenformel:
C13H20N2O3S
Molgewicht:
284.37
MOL-Datei:
23964-58-1.mol

Articaine Eigenschaften

Schmelzpunkt:
175-176 °C
Siedepunkt:
bp0.3 162-167°
Dichte
1.178±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
13.46±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Major Application
pharmaceutical (small molecule)
InChI
InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16)
InChIKey
QTGIAADRBBLJGA-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)SC=C(C)C=1NC(=O)C(NCCC)C
CAS Datenbank
23964-58-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  WGK 3
HS Code  2934990002
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

Articaine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Articaine [4-methyl-3-(2-propylaminopropionamido) thiophene-2-carboxylic acid methyl ester hydrochloride] has been widely used in dentistry since its approval by the U.S. FDA in the year 2000 because of its quick onset and short duration of action. The structure of articaine differs from those of all other amino amide-type local anesthetics in that it contains a thiophene ring instead of a benzene ring and a carbomethoxy group. This renders the molecule more lipophilic and, thus, easier to cross any lipoidal membranes.
Its local anesthetic potency is approximately 1.5-fold that of lidocaine, even though it has similar pKa (7.8) and plasma protein binding (76%) properties. Articaine also is metabolized primarily by plasma cholinesterases because of the presence of an ester group and, therefore, has a much shorter duration of action than lidocaine (i.e., only approximately one-fourth that of lidocaine). Articaine undergoes rapid hydrolysis of the carbomethoxy group to give articainic acid, which is eliminated either unchanged (75%) or as its glucuronides (25%). Compared with to other shortacting, amino amide-type local anesthetics, such as mepivacaine, lidocaine, or prilocaine, articaine is said to be a much safer drug for regional anesthesia and is the drug of choice for dental procedures.

Verwenden

Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand , food surgery and in dentistry.

Kontakt-Allergie

This local amide-type anesthetic is seldom reported as allergenic even in patients sensitized to other amidetype molecules like lidocaine, prilocaine, mepivacaine, or bupivacaine.

Articaine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Articaine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 136)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Xiamen Wonderful Bio Technology Co., Ltd.
+8613043004613
Sara@xmwonderfulbio.com China 283 58
Hebei Ganmiao New material Technology Co., LTD
+86-17332992504
sales8@hbganmiao.com China 300 58
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191
Jerry@xhobio.com China 906 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8615060885618
sales@amoychem.com China 6366 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
CHINA 964 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
Hebei Miaobian Biotechnology Co., Ltd
+8617733850068
CHINA 967 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58

23964-58-1()Verwandte Suche:


  • ARTICAINE
  • methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate
  • 4-Methyl-3-[2-[propylamino] propionamido]-2-thiophenecarboxylic acid, methyl ester
  • 40045
  • 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester
  • 4-Methyl-3-[1-oxo-2-(propylamino)propylamino]-2-thiophenecarboxylic acid methyl ester
  • Articaina [inn-spanish]
  • Articainum
  • Articainum [inn-latin]
  • Methyl (4-methyl-3-(2-(propylamino)propionamido)-2-thiophencarboxylat)
  • Unii-D3sq406G9x
  • Articaine (40 mg)
  • 2-Thiophenecarboxylicacid, 4-Methyl-3-[[1-oxo-2-(propylaMino)propyl]aMino]-, Methyl ester
  • Aceclofenac EP IMpurity H
  • Articaine HCl (base)
  • articaine:methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate
  • Articaine 23964-58-1
  • Articaine (free base)
  • Articaine (1042907)
  • Articaine (USP)
  • Articaine Anesthetic Raw Powder
  • Articaine HCl Powder best price/first-class Articaine HCl Powder/23964-58-1 on offer
  • atecaine
  • ARTICAINE HCL
  • Articaina
  • Articain
  • Carticaine
  • 23964-58-1
  • 23964-97-0
  • C13H21ClN2O3S
  • C13H20N2O3S
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