Halofuginone hydrobromide
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- CAS-Nr.
- 64924-67-0
- Englisch Name:
- Halofuginone hydrobromide
- Synonyma:
- STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);CID 121225393;Unii-ptc2969mv1;RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Haloperidone hydrobromide;Changshan ketone hydrobromide
- CBNumber:
- CB91230111
- Summenformel:
- C16H17BrClN3O3.HBr
- Molgewicht:
- 495.59
- MOL-Datei:
- 64924-67-0.mol
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Halofuginone hydrobromide Eigenschaften
- Schmelzpunkt:
- 247° (dec)
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble to 100 mM in DMSO.
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Major Application
- forensics and toxicology
pharmaceutical (small molecule)
- InChI
- InChI=1/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/s3
- InChIKey
- SJUWEPZBTXEUMU-DWKGARMTNA-N
- SMILES
- C12C=C(C(Br)=CC=1N=CN(CC(=O)C[C@@H]1NCCC[C@H]1O)C2=O)Cl.Br |&1:14,19,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| RIDADR |
UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all |
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| WGK Germany |
3 |
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| RTECS-Nr. |
VA2397066 |
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| Speicherklasse |
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
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| Hazard Classifications |
Acute Tox. 1 Dermal
Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P262 |
Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Halofuginone hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).
Definition
The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
Biologische Aktivit?t
Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.
Toxikologie
Halofuginone HBr (Halofuginone hydrobromide) is toxic by inhalation, dermal and ocular routes and is very irritant to both the eye and the skin. It is considered also a skin sensitiser[1].
Halofuginone hydrobromide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Halofuginone hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 154)Lieferanten
64924-67-0()Verwandte Suche:
1-Brom-3-chlor-5,5-dimethylimidazolidin-2,4-dion
3'-Hydroxypropiophenon
Hydrogenbromid
1-[2-[(4-Chlorphenyl)phenylmethoxy]ethyl]piperidiniumchlorid
Dextromethorphan hydrobromide monohydrate
Chlorobromoisocyanurate
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
1-[3-(Dimethylamino)propyl]-1-(4-fluorphenyl)-1,3-dihydroisobenzofuran-5-carbonitrilmonohydrobromid
Trazodon
Pyridiniumbromid
1,3-Dihydroxyaceton
Galantaminhydrobromid
4,4'-[(2β,3α,5α,16β,17β)-3,17-Bis(acetoxy)androstan-2,16-diyl]bis[1,1-dimethylpiperazinium]dibromid
Halofuginone
Hydroxyacetone
HYOSCINE N BUTYL BROMIDE BP
Benzolessigs?ure, alpha-(hydroxymethyl)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl-ester, (7(S)-(1 alpha, 2 beta,4 beta, 5 alpha, 7 beta))-hydrobromid
Chlordifluormethan
- Ru-19110
- Tempostatin
- Unii-ptc2969mv1
- rel-7-BroMo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone HydrobroMide
- trans-(+/-)-7-BroMo-6-chloro-3-[3-(3-hydroxy-2-
piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone MonohydrobroMide
- 7-BroMo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobroMide
- HALOFUGINONEHYDROBROMIDE
- STENOROL
- 7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one hydrobromide
- 4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,hydrobromide (1:1), rel-
- (+/-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide
- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide, rel-
- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)-
- 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+/-)-
- Trans-halofuginone hydrobromide
- HALOFUGINONE HBR ((2R,3S) AND (2S,3R) MIXTURE)
- Halofuginone Hydrobromide 64924-67-0
- (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
- RU-19110(HBr)
- RU-19110 (hydrobromide)
- 7-Bromo-6-chloro-3-(3-((2S,3R)-rel-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide
- Haloperidone hydrobromide
- (3R,4R)-4-(2,5-Difluoro-phenyl)-3-methyl-4-[1,2,4]triazol-1-ylmethyl-oxetan-2-one
- Halofuginone hydrobromide 100 μg/ml Acetonitrile
- CID 121225393
- Halofuginone hydrobromide, 10 mM in DMSO
- Changshan ketone hydrobromide
- 1-Hydrogen Bromo acid halofiber ketone
- 64924-67-0
- C16H18Br2ClN3O3
- Amines
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
