Glycopyrronium Bromide
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- CAS-Nr.
- 51186-83-5
- Englisch Name:
- Glycopyrronium Bromide
- Synonyma:
- Glicopirrolato;Glonium bromide;GLYCOPYRRONIUM BROMIDE;Glycopyrtonium Bromide;GlycopyrroniuM BroMide API;Glycopyrrolate Impurity 58;erythro-Glycopyrronium bromide;Glycopyrronium bromide
(CHF 5259;Glycopyrronium
Bromide /
Glycopyrrolate;2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid (triglycine)
- CBNumber:
- CB91270476
- Summenformel:
- C19H28NO3.Br
- Molgewicht:
- 0
- MOL-Datei:
- 51186-83-5.mol
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Glycopyrronium Bromide Eigenschaften
- Schmelzpunkt:
- 175℃
- L?slichkeit
- Freely soluble in water, soluble in ethanol (96 per cent), very slightly soluble in methylene chloride.
- InChI
- InChI=1/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1/t17-,19-;/s3
- InChIKey
- VPNYRYCIDCJBOM-SCHKGOGONA-M
- SMILES
- [N+]1(C)(C)CC[C@H](OC([C@](C2CCCC2)(O)C2=CC=CC=C2)=O)C1.[Br-] |&1:5,8,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Glycopyrronium Bromide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Glycopyrronium bromide or NVA 237 is a once-daily inhaled antimuscarinic bronchodilator newly approved by the European Commission for use in stable COPD. It is characterized by a quaternary ammonium structure, which reduces its oral bioavailability and, consequently, the systematic effects of any swallowed portion of the drug.
Animal studies suggest that there are fewer cardiovascular effects compared to tiotropium because of the higher affinity to M3 versus M2 muscarinic receptors. Human studies showed fast onset of action, sustained bronchodilatation for 24 h, reduced dynamic hyperinflation of the lungs, and improved exercise tolerance. Glycopyrronium bromide in COPD airways clinical trial series (GLOW1–3) are the major clinical trials studying the efficacy and safety of glycopyrronium[1].
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
erythro-Glycopyrronium Bromide is used in preparation of diester containing compounds for treating hyperhidrosis.
Indications
Glycopyrronium bromide is indicated for use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions; to reduce the volume and free acidity of gastric secretions, and to block cardiac vagal inhibitory reflexes during induction of anaesthesia and intubation when indicated. Glycopyrronium bromide may be used intraoperatively to counteract drug-induced or vagal traction reflexes with the associated arrhythmias. Glycopyrronium bromide protects against the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) of cholinergic agents such as neostigmine and pyridostigmine given to reverse the neuromuscular blockade due to non-depolarising muscle relaxants.
Glycopyrronium Bromide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Glycopyrronium Bromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 100)Lieferanten
51186-83-5()Verwandte Suche:
- erythro-Glycopyrronium bromide
- Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-
- Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide, (R*,S*)-(+-)-
- (R*,S*)-3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide
- GlycopyrroniuM BroMide API
- (3S)-3-{[(2R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy}-1,1-dimethylpyrrolidinium bromide
- Glycopyrronium bromide
(CHF 5259
- Glycopyrronium for peak identification (Y0001309)Q: What is
Glycopyrronium for peak identification (Y0001309) Q: What is the CAS Number of
Glycopyrronium for peak identification (Y0001309)
- 2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetic acid (triglycine)
- Glycopyrronium
Bromide /
Glycopyrrolate
- (3S)-rel-3-[[(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethyl-,Pyrrolidinium bromide (1:1)
- Glonium bromide
- GLYCOPYRRONIUM BROMIDE
- Glycopyrrolate Impurity 58
- Glycopyrtonium Bromide
- Glicopirrolato
- 51186-83-5
