Risperidone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Risperidone is a novel antipsychotic introduced for the treatment of acute and chronic schizophrenia. It has a balanced serotonin 5-HT₂ and dopamine D₂ receptor antagonist activity. While the anti-D₂ activity may relate to the antipsychotic potency of neuroleptic agents, an antidepressive efficacy of substances with anti-5-HT₂ activity has been suggested. Risperidone, therefore, has therapeutic action on both positive and negative symptoms of schizophrenia and produces significantly fewer side effects especially extrapyramidal symptoms compared with commonly used pure D₂ antagonist antipsychotics. It also has potential for management of alcohol withdrawal and cocaine addiction.

Chemische Eigenschaften

Crystalline Solid

History

Risperidone, developed by Johnson & Johnson Innovative Medicine and marketed under the brand name Risperdal, is an atypical antipsychotic. It was first approved by the FDA in December 1993 for schizophrenia and bipolar disorder. In October 2006, Risperdal was approved for the treatment of irritability associated with autism. With further research, by October 2025, Risperidone (brand name UZEDY) was approved as a sustained-release injection suspension for the maintenance treatment of adult bipolar I disorder, as a monotherapy or adjunctive therapy to lithium or valproate.

Verwenden

Risperidone has been used:

• to study its effects on bone formation and differentiation
• to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients
• to reverse induced schizophrenia-like behavior in mice

Definition

ChEBI: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

Allgemeine Beschreibung

Risperidone (Risperdal, a benzisoxazole)has the structural features of a hybrid molecule between abutyrophenone antipsychotic and a trazodone-like antidepressant.Its superior side effects profile (compared withhaloperidol) at dosage of 6 mg/d or less and the lower riskof tardive dyskinesia have contributed to its very widespreaduse. It benefited refractory psychotic patients, withparkinsonism controlled at one tenth the dose of antiparkinsoniandrugs used with haloperidol.Coexisting anxietyand depressive syndromes were also lessened. It is reportedto decrease the negative (e.g., withdrawal, apathy) as well asthe positive (e.g., delusions, hallucinations) symptoms ofschizophrenia. This is reportedly a consequence of the compound’scombination 5-HT₂–D₂ receptor antagonistic properties.Overall, the reasons for the decreased EPS and effectiveness against negative symptom are still under investigation.It is an important atypical antipsychotic.Risperidone is metabolized in the liver by CYP2D6 to anactive metabolite, 9-hydroxyrisperidone. Because thismetabolite and risperidone are nearly equipotent, the clinicalefficacy of the drug reflects both compounds.

Biologische Aktivit?t

Atypical antipsychotic agent that displays 5-HT 2A receptor antagonism. Also displays high affinity at D 2 receptors (K i values are 0.4 and 3.13 nM for 5-HT 2A and D 2 receptors respectively).

Risperidone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Risperidone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2452	58
Shaanxi Haibo Biotechnology Co., Ltd	+86-18629295024	qinhe02@xaltbio.com	China	996	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +86-13675893055	info@hyper-chem.com	China	309	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +86-17709210191	Jerry@xhobio.com	China	901	58
Moxin Chemicals	+86-17320513646 +86-17320513646	anna@molcoo.com	China	9998	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6361	58

106266-06-2()Verwandte Suche:

---

• 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-
• 4-[2-[4-(6-Fluorobenzo[d]isoxazol-3-yl)-1-piperidyl]ethyl]-3-methyl-2,6-diazabicyclo[4.4.0]deca-1,3-dien-5-one
• Risoeridone
• 3-[2-[4-(6-Fluoro-1，2-benzrsoxazol-3-yl)-1-piperidinyl]ethyl]-6，7，8，9-tetmhydro-2-methyl-4H-pyrido[1，2-α]pyrimidin-4-one
• 3-[2-[4-(6-Fluoro-1,2-benzoisoxazole-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one
• Rispadal
• Risperdal OD
• Risperidone, USP
• Risperidone (200 mg)
• 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-Methyl-6,7,8,9
• 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-Methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyriMidin-4-one
• Apexidone
• Psychodal
• Spiron
• Risperidone( R 64 766,Risperdal)
• Methanol（ Test Risperidone, 1.0 mg/mL）
• 4h-pyrido(1,2-a)pyrimidin-4-one,6,7,8,9-tetrahydro-3-(2-(4-(6-fluoro-1,2-benzi
• soxazol-3-yl)-1-piperidinyl)ethyl)-2-methyl-
• R-64766
• RISPERIDONE
• BELIVON
• 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
• 3-[2-4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL-6,7,8,9-TETRAHYDRO-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
• 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-
• 3-[2-4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, R-64766, Belivon, Risperdal
• Kesperidone
• 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2,a]pyrimidin-4-one
• 1,2-Benzisoxazole, 4H-pyrido[1,2-a]pyrimidin-4-one deriv.
• 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl- (9CI)
• 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[2,1-b]pyrimidin-4-one
• 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyriMidin-4-one
• Risperidal 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• Risperidone solution
• 4h-pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-
• Risperidal and Intermediates
• 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
• Risperidone, 99.5%, Dopamine, serotonin, adrenergic and histamine receptors antagonist
• Risperidone(R 64 766)
• R 64 766; RISPERDAL
• CS-2004
• Risperidone CRS
• Risperidone for system suitability CRS
• Risperidone>
• Risperidone Product
• High Quality Risperidone Raw Powder
• Risperidone USP/EP/BP
• Risperidone (R1000600)Q: What is Risperidone (R1000600) Q: What is the CAS Number of Risperidone (R1000600)
• RisperidoneQ: What is Risperidone Q: What is the CAS Number of Risperidone Q: What is the storage condition of Risperidone Q: What are the applications of Risperidone
• Risperidone for system suitability (Y0000370)
• Risperidone (1604654)
• 3-[2-4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one, R-64766, Belivon, Risperdal
• Risperidone(Risperdal)
• RISPERDAL
• RISPERIDAL
• Risperdal Consta
• 6-Benzofuranbutanoicacid,α,γ-dioxo-,ethylester
• Risperidone in Methanol
• Risperidone, 5-HT2A / D2 antagonist