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indicine-N-oxide

indicine-N-oxide Struktur
41708-76-3
CAS-Nr.
41708-76-3
Englisch Name:
indicine-N-oxide
Synonyma:
NSC132319;Indicin-N-oxid;indicine-N-oxide;Indicine N-oxide-RM;(+)-Indicine N-oxide;Indicine N-oxide (Standard);DNAWGBOKUFFVMB-PZIGJSDBSA-N;(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate;Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aS)-2,3,5,7a-tetrahydro-1-hydroxy-4-oxido-1H-pyrrolizin-7-yl]methyl ester, (2R,3S)-
CBNumber:
CB91364920
Summenformel:
C15H25NO6
Molgewicht:
315.36
MOL-Datei:
41708-76-3.mol

indicine-N-oxide Eigenschaften

Schmelzpunkt:
130.5°C (rough estimate)
Siedepunkt:
454.91°C (rough estimate)
Dichte
1.1359 (rough estimate)
Brechungsindex
1.5000 (estimate)
pka
12.54±0.29(Predicted)

Sicherheit

RIDADR  1544
HazardClass  6.1(b)
PackingGroup  III

indicine-N-oxide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Heliotropiurn indicurn also contains this base which has the structure given above based upon comparison with the preceding alkaloid. The base has proved to be highly active against transplanted neoplasts, Walker-256 carcinosarcoma, melanoma B-16, leukaemia L-12l 0, leukaemia P-388 and leukaemia P-1534 in mice and rats, giving up to 91 per cent inhibition of transplanted growth at a daily dosage of 200 mgm. per kilo.

Verwenden

Indicine N-oxide is a pyrrolizidine alkaloid that is isolated from Heliotropium indicum, one of the most widely used herbs in India. Indicine N-oxide exhibits antitumour and antimitotic activity in humans, and has subsequently undergone Phase I & II trials in adults and children with leukemia and solid tumours.

Einzelnachweise

Rao, McBride., U.S. Patent, 3,717,710 February 20,1973

indicine-N-oxide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


indicine-N-oxide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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41708-76-3()Verwandte Suche:


  • indicine-N-oxide
  • Indicin-N-oxid
  • DNAWGBOKUFFVMB-PZIGJSDBSA-N
  • Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aS)-2,3,5,7a-tetrahydro-1-hydroxy-4-oxido-1H-pyrrolizin-7-yl]methyl ester, (2R,3S)-
  • (7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate
  • (+)-Indicine N-oxide
  • NSC132319
  • Indicine N-oxide-RM
  • Indicine N-oxide (Standard)
  • 41708-76-3
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