dibromophakellstatin Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
Dibromophakellstatin was synthesised from (S,S)-cyclo(Pro,Pro) as the starting material by a series of chemical reactions. Key steps in the synthesis were a desymmetrization of the diketopiperazine (S,S)-cyclo (Pro, Pro) via a diastereoselective acylation, an intramolecular Mitsunobu reaction to introduce the C6 aminal, and a tandem Hofmann rearrangement/cyclization to simultaneously introduce the C10 quaternary aminal center and deliver the cyclic urea. The reaction route is as follows:
dibromophakellstatin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
