Profenofos Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
R24:Giftig bei Berührung mit der Haut.
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S9:Beh?lter an einem gut gelüfteten Ort aufbewahren.
S7:Beh?lter dicht geschlossen halten.
Beschreibung
Profenofos is a pale yellow liquid, bp 100 C/1.80 Pa, vp
0.124 mPa (25 C). Solubility in water is 28 mg/L (25 C).
It is miscible with most organic solvents. Log Kow = 4.44.
It is relatively stable in neutral and mild acid media but
hydrolyzed in alkaline media; DT
50 values (20 C) at pH 5,
7, and 9 are 93 d, 14.6 d, and 5.7 h, respectively.
Chemische Eigenschaften
Profenofos is a pale yellow liquid. Profenofos is relatively
stable under neutral and slightly acidic conditions and unstable
under alkaline conditions.Profenofos has a garlic-like odor.
Profenofos has limited solubility in water
(28 mg/L at 25°C) but is completely soluble
in organic solvents (ethanol, acetone, toluene,
n-octanol and n-hexane) at 25°C.
Verwenden
Profenofos is used to control insects (particularly caterpillars and
Lepidoptera eggs) and mites on cotton, maize, sugar beet, soyabean,
potatoes, vegetables, tobacco and a number of other crops
Allgemeine Beschreibung
Pale yellow liquid with garlic-like odor. Corrosive. Used as an insecticide.
Air & Water Reaktionen
Hydrolyzed under alkaline conditions.
Reaktivit?t anzeigen
Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Landwirtschaftliche Anwendung
Profenofos: Profenofos is A U.S. EPA restricted Use Pesticide (RUP) used solely on cotton to control a number of pests including tobacco budworm, cotton aphid and bollworm, armyworm, fleahopper and whiteflies. It is not registered for residential use. Not approved for use in EU countries. Registered for use in the U.S.
Handelsname
CGA-15324®; CURACRON®; POLYCRON®; SELECRON®
Synthese
The commercial production of profenofos involves synthesis through a chemical process that typically starts with phosphorus oxychloride, which is reacted with sodium ethoxide and sodium 1-propanethiolate, followed by treatment with 4-bromo-2-chlorophenol. This yields the active compound used in agricultural formulations.
Carcinogenicity
In a 2 year carcinogenicity study
mice were given diets containing 0, 1, 30, or 100 ppm profenofos
(equivalent to 0, 0.15, 4.5, or 15 mg/kg/day) for 85
weeks (males) or 97 weeks (females) . No treatment related clinical signs were observed. No treatment-related
gross or microscopic lesions, tumors, or biologically significant
differences in body weight or food consumption were
observed between controls and profenofos-treated animals.
Plasma and erythrocyte cholinesterase inhibition occurred at
dose levels of 4.5 and 15 mg/kg/day.
In another carcinogenicity study, rats were fed diets containing
0, 0.3, 10, or 100 ppm profenofos (equivalent to 0,
0.015, 0.5, or 5 mg/kg/day) for 2 years, and there was no
increase in tumor incidence in any treated group compared to
the control group .
Environmental Fate
Plant. Dislodgable residues of profenofos on cotton leaf 0, 24, 48, 72 and 96 hours
after application (1.1 kg/ha) were 3.5, 1.1, 0.74, 0.51 and 0.35 μg/m2, respectively (Buck
et al., 1980)
Photolytic. When profenofos in an aqueous buffer solution (pH 7.0) was exposed to
filtered UV light (λ >290 nm) for 24 hours at 25 and 50°C, 29 and 61% respectively
decomposed to 4-bromo-2-chlorophenol and 4-bromo-2-chlorophenyl ethyl hydrogen
ph
Chemical/Physical. Emits toxic fumes of bromine, chlorine phosphorus and sulfur
oxides when heated to decomposition (Sax and Lewis, 1987).
Stoffwechselwegen
The metabolic transformations of profenofos in plants and animals are
similar and occur via hydrolysis to 4-bromo-2-chlorophenol which is then
conjugated.
Stoffwechsel
Profenofos
orally administered to rats is rapidly excreted, mainly in
the urine. The principal degradation route is hydrolysis to
4-bromo-2-chlorophenol followed by conjugation. DT
50 in
soil is about 1 week.
Profenofos Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
