3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
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- CAS-Nr.
- 497061-48-0
- Englisch Name:
- 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
- Synonyma:
- DC_AC50;DC_AC50
(DC-AC50;DC_AC50 >=98% (HPLC);DC_AC50, 10 mM in DMSO;3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide;5H-Cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide, 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-;DC_AC-50,resistance,DC_AC50,osteosarcoma,CCS,copper,chaperones,Atox1,inhibit,Apoptosis,Chemotherapy,Inhibitor
- CBNumber:
- CB92001813
- Summenformel:
- C17H12BrF2N3OS
- Molgewicht:
- 424.26
- MOL-Datei:
- 497061-48-0.mol
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3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide Eigenschaften
- Siedepunkt:
- 485.1±45.0 °C(Predicted)
- Dichte
- 1.759±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO
- pka
- 8.80±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to light brown
- InChI
- 1S/C17H12BrF2N3OS/c18-10-5-8(19)6-11(20)14(10)23-16(24)15-13(21)9-4-7-2-1-3-12(7)22-17(9)25-15/h4-6H,1-3,21H2,(H,23,24)
- InChIKey
- DFNOJNBNTVQPCA-UHFFFAOYSA-N
- SMILES
- NC1=C(C(NC2=C(Br)C=C(F)C=C2F)=O)SC3=NC4=C(CCC4)C=C31
3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Biochem/physiol Actions
DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport. Cancer cells rely more heavily on Atox1 and CCS than normal cells. DC_AC50 blockade of copper trafficking induces cellular oxidative stress, affecting cancer cells more strongly than normal cells, and leading to the inhibition of cancer cell proliferation.
3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 45)Lieferanten
- 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
- DC_AC50
(DC-AC50
- 5H-Cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide, 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-
- DC_AC50 >=98% (HPLC)
- DC_AC-50,resistance,DC_AC50,osteosarcoma,CCS,copper,chaperones,Atox1,inhibit,Apoptosis,Chemotherapy,Inhibitor
- DC_AC50, 10 mM in DMSO
- DC_AC50
- 497061-48-0
- C17H12BrF2N3OS
