D609
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- CAS-Nr.
- 83373-60-8
- Englisch Name:
- D609
- Synonyma:
- D609;D609 ,98%;D609,D-609;D-609 POTASSIUM;D609 POTASSIUM SALT;D609, 10 mM in DMSO;D609 potassium salt,98%;Tricyclodecan-9-yl xanthate;Tricyclodecan-9-yl xanthogenate;tricyclodecane-9-yl-xanthogenate
- CBNumber:
- CB9249743
- Summenformel:
- C11H17KOS2
- Molgewicht:
- 268.47
- MOL-Datei:
- 83373-60-8.mol
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D609 Eigenschaften
- storage temp.
- 0-6°C
- L?slichkeit
- H2O: 300 mg/mL
- Aggregatzustand
- solid
- Farbe
- off-white
- Biologische Quelle
- synthetic (organic)
- Wasserl?slichkeit
- Soluble to 100 mM in water
- InChI
- 1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1/t6-,7,8,9-,10;/m1./s1
- InChIKey
- IGULCCCBGBDZKQ-HJPGVBIPSA-M
- SMILES
- [K]SC(=S)OC1CC2CC1C3CCCC23
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| R-S?tze: |
22 |
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| S-S?tze: |
24/25 |
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| WGK Germany |
3 |
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| HS Code |
29333990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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D609 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; K
i = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA
2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC
50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
Chemische Eigenschaften
white to off-white solid
Verwenden
D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E
-/- mice.
Biologische Aktivit?t
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .
D609 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
D609 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 112)Lieferanten
83373-60-8()Verwandte Suche:
- Tricyclodecan-9-yl xanthate
- Tricyclodecan-9-yl xanthate potassium salt
- Tricyclodecan-9-yl xanthogenate
- D609 potassium salt,98%
- Carbonodithioic acid O-(octahydro-4,7-methano-1H-inden-5-yl) ester potassium salt
- tricyclodecane-9-yl-xanthogenate
- D609 ,98%
- CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METH
- TRICYCLODECAN-9-YL XANTHOGENATE K
- TRICYCLODECAN-9-YL XANTHOGENATE POTASSIUM SALT
- CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) ESTER POTASSIUM
- D609
- D-609 POTASSIUM
- D609 POTASSIUM SALT
- O-TRICYCLO[5.2.1.0(2,6)]DEC-9-YL DITHIOCARBONATE POTASSIUM SALT
- O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) CARBONOPOTASSIUM DITHIOATE
- potassium O-(octahydro-4,7-methano-1H-inden-5-yl) dithiocarbonate
- O-TRICYCLO(5.2.1.02,6)DEC-9-YL*DITHIOCAR BONATE POTA
- Dithiocarbonic acid O-[(octahydro-4,7-methano-1H-inden)-5-yl]S-potassium salt
- D609, Potassium Salt - CAS 83373-60-8 - Calbiochem
- O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate
- D609,O-(Octahydro-4,7-methano-1H-inden-5-yl)carbonopotassiumdithioate
- potassium O-(octahydro-1H-4,7-methanoinden-5-yl) carbonodithioate
- D609,D-609
- D609, 10 mM in DMSO
- O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt
- Potassium O-(octahydro-1H-4,7-methanoinden-5-yl) carbonodithioate , D609
- 83373-60-8
- C11H15KOS2
- Biochemicals and Reagents
- BioChemical
- P to Q
- Phospholipase C, phosphatidylcholine-specific
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors
- Enzymes, Inhibitors, and Substrates
- Lipid signaling
