Dabigatran Etexilate Mesylate
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- CAS-Nr.
- 872728-81-9
- Englisch Name:
- Dabigatran Etexilate Mesylate
- Synonyma:
- Pradaxa;Pradaxa Mesylate;Dabigatran mesylate;Dabigatran Etexilate Mesylate API;Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-;Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate;(E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate;ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat;Dabig
- CBNumber:
- CB92500679
- Summenformel:
- C35H45N7O8S
- Molgewicht:
- 723.85
- MOL-Datei:
- 872728-81-9.mol
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Dabigatran Etexilate Mesylate Eigenschaften
- Schmelzpunkt:
- >125°C
- storage temp.
- Refrigerator
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
- Major Application
- pharmaceutical
- InChIKey
- XETBXHPXHHOLOE-UHFFFAOYSA-N
- SMILES
- S(O)(=O)(=O)C.CN1C(=NC2C=C(C(=O)N(C3N=CC=CC=3)CCC(=O)OCC)C=CC1=2)CNC1C=CC(C(=N)NC(=O)OCCCCCC)=CC=1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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Dabigatran Etexilate Mesylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White to Pale Yellow Solid
History
Dabigatran Etexilate Mesylate (brand name pradaxa) was discovered from a panel of chemicals with similar structure to benzamidine-based thrombin inhibitor α-NAPAP (N-alpha-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide). Addition of ethyl ester and hexyloxycarbonyl carbamide hydrophobic side chains led to the orally absorbed prodrug, BIBR 1048 (dabigatran etexilate).
In March 2008, the European Medicines Agency (EMA) granted marketing authorization for Pradaxa for the prevention of thromboembolic disease following hip or knee replacement surgery and for non-valvular atrial fibrillation.
The National Health Service (NHS) in Britain authorized dabigatran for use in preventing blood clots in hip and knee replacement surgery patients.
Pradaxa received a Notice of Compliance (NOC) from Health Canada in June 2008,[45] for the prevention of blood clots in patients who have undergone total hip or total knee replacement surgery. Approval for atrial fibrillation patients at risk of stroke came in October 2010.
The U.S. Food and Drug Administration (FDA) approved Pradaxa in October 2010, for prevention of stroke in patients with non-valvular atrial fibrillation.
In February 2011, the American College of Cardiology Foundation and the American Heart Association added dabigatran to their guidelines for management of non-valvular atrial fibrillation with a class I recommendation.
Verwenden
Nonpeptide, direct thrombin inhibitor. Antithrombotic.
Clinical Use
Dabigatran Etexilate Mesylate is a direct thrombin inhibitor indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
Definition
ChEBI: A methanesulfonate salt obtained by reaction of dabigatran etexilate with one equivalent of dabigatran etexilate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.
Trademarks
Pradaxa
Dabigatran Etexilate Mesylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dabigatran Etexilate Mesylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 547)Lieferanten
872728-81-9()Verwandte Suche:
- Dabigatran etexilate mesylate
- (Z)-ethyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate
- Dabigatran etexilate mesylate,Pradaxa
- Dabigatran etexilate Mesylate 872728-81-9
- [[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanineethylesterMonoMethanesulfonat
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-y
- BIBR 1048MS
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine Ethyl Ester Methanesulfonate
- Dabigatran etexilate Methanesulfonate
- PRADAXA; BIBR 1048MS; DABIGATRAN ETEXILATE METHANESULFONATE
- ate MesyL
- atran EtexiL
- Dabig
- Dabigatran EtexiL
- Dabigatran Etexilate Mesylate USP/EP/BP
- Dabigatran Etexilate Mesylate Pellet
- Dabigatran Etexilate Mesylate- IH
- B-Alanine, N-[[2-[[[4-[[[(hexyloxy) carbonyl] amino] iminomethyl] phenyl] amino] methyl]-1-methyl-1H-benzimidazol-5-yl] carbonyl]-N-2-pyridinyl -,ethyl ester, methanesulfonate
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl] amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine ethyl ester methanesulfonate
- Dabigatran Etexilate MesylateQ: What is
Dabigatran Etexilate Mesylate Q: What is the CAS Number of
Dabigatran Etexilate Mesylate Q: What is the storage condition of
Dabigatran Etexilate Mesylate Q: What are the applications of
Dabigatran Etexilate Mesylate
- Dabigatran Mesylate Reference
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat supplier in Chin
- CS-900
- 3-([2-[[(4-(N-n-hexyloxycarbonylcarbamimidoyl)-phenylamino)-methyl]]-1-methyl-1H-benzimidazole-5-carbonyl]-pyridin-2-yl-amino)ethyl propionate mesylate
- Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat
- Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate
- (E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate
- Dabigatran Etexilate Mesylate API
- ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate
- Dabigatran etexilatemesi
- Pradaxa, Dabigatran etexilate mesylate
- DabigatranEtexilate Mesylate/Pellets
- Dabigatran Etexilate Mesylate, 10 mM in DMSO
- DABIGATRAN ETEXILATE MESYLATE [DRUG SUBSTANCE (NON-STERILE)]
- Dabigatran Etexilate Mesylate: N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino] iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-?-Alanine- ethyl ester methanesulfonate
- Pradaxa Mesylate
- Dabigatran mesylate
- Pradaxa
- 872728-81-9
- C34H41N7O5CH4O3S
- C35H45N7O8S
- Aromatics
- Bases & Related Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Dabigatran etexilate mesylate
- API
- 872728-81-9
