KU57788(NU7441) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC₅₀ value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC₅₀ values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

KU57788(NU7441) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

KU57788(NU7441) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20581	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

503468-95-9()Verwandte Suche:

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• KU57788(NU7441)
• NU 7441
• 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
• 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
• NU7441 (KU-57788);KU 57788; NU-7441
• KU 57788
• NU-7441 (KU-57788)
• 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)-
• 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441
• NU 7441 (This product is only available in Japan.)
• CS-181
• NU 7441 - KU 47788
• NU7441;KU57788;NU 7441 (KU 57788)
• 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one
• KU57788(NU7441) USP/EP/BP
• KU-57788, 10 mM in DMSO
• 503468-95-9
• Inhibitors
• Heterocycles
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Sulfur & Selenium Compounds