O-Desmethyl-N-deschlorobenzoyl Indomethacin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light Brown Solid
Verwenden
O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin. It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (PGD2) receptor antagonists.
Einzelnachweise
[1] KAZUHIKO TORISU . Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead[J]. European Journal of Medicinal Chemistry, 2005, 40 5: Pages 505-519. DOI:
10.1016/j.ejmech.2004.11.011.
[2] M A EVANS. Indomethacin Metabolism in Isolated Neonatal and Fetal Rabbit Hepatocytes[J]. Pediatric Research, 1981, 15 11: 1406-1410. DOI:
10.1203/00006450-198111000-00003.
[3] ANDREW G.M. MORGAN . An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity[J]. Toxicology letters, 2017, 280: Pages 48-56. DOI:
10.1016/j.toxlet.2017.07.894.
[4] KAZUHIKO TORISU . Discovery of new chemical leads for prostaglandin D2 receptor antagonists[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 17: Pages 4557-4562. DOI:
10.1016/j.bmcl.2004.06.006.
O-Desmethyl-N-deschlorobenzoyl Indomethacin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
