3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
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- CAS-Nr.
- 338967-87-6
- Englisch Name:
- 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- Synonyma:
- Mdivi 1;4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-;Mdivi;CS-951;Mdivi1/Mdivi-1;Mdivi-1 ，S7162;Mdivi-1, 338967-87-6;Mdivi-1, 10 mM in DMSO;Mdivi-1, Drp1 inhibitor;Mitochondrial division inhibitor 1
- CBNumber:
- CB92518885
- Summenformel:
- C15H10Cl2N2O2S
- Molgewicht:
- 353.22
- MOL-Datei:
- 338967-87-6.mol
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Eigenschaften
- Schmelzpunkt:
- 289 °C
- Siedepunkt:
- 522.5±60.0 °C(Predicted)
- Dichte
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: >20mg/mL
- Aggregatzustand
- White solid
- pka
- 9.91±0.20(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
- InChIKey
- NZJKEVWTYMOYOR-UHFFFAOYSA-N
- SMILES
- COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2933.59.8000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1; IC
50 = ~1-10 μM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 μM. Mdivi 1 (50 μM) inhibits mitochondrial fragmentation and DRP1 self-assembly induced by staurosporine in COS cells overexpressing DRP1. It induces apoptosis in, and inhibits colony formation of, A549 cells when used at concentrations of 25 and 50 μM, respectively. Mdivi 1 (1 μM) decreases doxorubicin-induced increases in infarct-to-risk ratios in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury. It reduces the severity of lung injury in a mouse model of LPS-induced acute lung injury when administered at a dose of 20 mg/kg.
Verwenden
Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.
Allgemeine Beschreibung
Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 211)Lieferanten
338967-87-6()Verwandte Suche:
- 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- Mdivi1/Mdivi-1
- Mitochondrial division inhibitor 1
- 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-THIOXO-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE EXACT
- Mitochondrial Division Inhibitor, mdivi-1
- 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi-1
- Mitochondrial division inhibitor 1 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- Mdivi-1, 338967-87-6
- Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
- CS-951
- MDIVI 1;MDIVI1;MITOCHONDRIAL DIVISION INHIBITOR 1
- 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
- 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone USP/EP/BP
- Mdivi-1 (Mitochondrial division inhibitor 1)
- Mdivi
- 4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-
- 3-(2,4-Dichloro-5-methoxyphenyl)-2-mercaptoquinazolin-4(3H)-one
- Mitochondrial Autophagy,Mitochondrial division inhibitor1,Inhibitor,inhibit,Autophagy,Mitophagy,Mdivi 1,Mdivi1,Mitochondrial division inhibitor-1,Dynamin,Apoptosis,Mdivi-1
- Mdivi-1, Drp1 inhibitor
- Mdivi-1, 10 mM in DMSO
- Mdivi-1 ，S7162
- Mdivi-1
≥98% (HPLC), powder, mitochondrial division DRP inhibitor
- Mdivi 1
- 338967-87-6
- C25H10Cl2N2O2S
- Inhibitors
