4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
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- CAS-Nr.
- 694499-26-8
- Englisch Name:
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- Synonyma:
- PON50;SW-53;SWF-53;AP24592;RMA-315;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Intermediate of Ponatinib;4-(4-Methylpiperazinomethyl)-3-
- CBNumber:
- CB92520701
- Summenformel:
- C13H18F3N3
- Molgewicht:
- 273.3
- MOL-Datei:
- 694499-26-8.mol
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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Eigenschaften
- Siedepunkt:
- 329.1±42.0 °C(Predicted)
- Dichte
- 1.227
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.55±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Light yellow to yellow
- InChI
- InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
- InChIKey
- ZMWAZMYBMAAMAW-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline is a pale yellow to yellow solid at room temperature, with a predicted boiling point of 329.1±42.0°C (760 mmHg), a density of 1.227 g/cm3 (or 1.2±0.1 g/cm3), a predicted pKa of 7.55±0.10, a flash point of 152.9±27.9°C, a refractive index of 1.529, and an extremely low vapor pressure (0.0±0.7 mmHg at 25°C). It needs to be stored at 2-8°C in a light-protected, sealed environment under an inert gas (nitrogen or argon) atmosphere.
Verwenden
4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.
Synthese
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).
Lager
Store long-term at 2-8°C.
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 242)Lieferanten
694499-26-8()Verwandte Suche:
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
- 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine
- 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
- 4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzenamine
- BenzenaMine, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)-
- 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)aniline
- 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline 95+%
- 5-Amino-2-[(4-methylpiperazin-1-yl)methyl]benzotrifluoride, 1-[4-Amino-2-(trifluoromethyl)benzyl]-4-methylpiperazine
- 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine
- Ponatinib Impurity 3
- Ponatinib int2
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock COA TDS free sample
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline TDS msds coa
- PON50
- 4-(4-METHYLPIPERAZINOMETHYL)-3-(TRIFLUOROMETHYL)ANILINE 694499-26-8
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP
- SWF-53
- SW-53
- Benzenamine, 4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoro...
- 3-(trifluoromethyl)-4-((4-methylpiperazin-1-yl)methyl)benzenamine
- 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline-d8
- 4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline
- 1-[4-Amino-2-(Trifluoromethyl)benzyl]-4-MethylPiperazine
- 4-(4-Methylpiperazinomethyl)-3-
- Pralsetinib Impurity 1
- Intermediate of Ponatinib
- AP24592
- 3-(Trifluoromethyl)-4-[(4-methylpiperazin-1-yl)methyl]aniline
- RMA-315
- (E)-3-((2-(2-cyanovinyl)-1H-imidazol-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
- 694499-26-8
