F-AMidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

F-AMidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

F-AMidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19956	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	57422	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24958	58
Santa Cruz Biotechnology Inc	--	scbt@scbt.com	China	6594	58

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• F-AMidine
• N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide
• F amidine,Famidine
• Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-
• 877617-45-3
• Amines
• Aromatics
• Inhibitors
• Intermediates & Fine Chemicals
• Pharmaceuticals