N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine
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- CAS-Nr.
- 413611-93-5
- Englisch Name:
- N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine
- Synonyma:
- 10074-G5;10074-g;10074G5;10074 G5;c-Myc Inhibitor II;10074-G5 >=98% (HPLC);10074-G5, 10 mM in DMSO;c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem;N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine;Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine;N-(2-Biphenylyl)-4-amino-7-nitrobenzo[c][1,2,5]oxadiazole
- CBNumber:
- CB92582970
- Summenformel:
- C18H12N4O3
- Molgewicht:
- 332.31
- MOL-Datei:
- 413611-93-5.mol
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N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Eigenschaften
- Siedepunkt:
- 538.6±60.0 °C(Predicted)
- Dichte
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: >10mg/mL
- pka
- -2.06±0.50(Predicted)
- Aggregatzustand
- powder
- Farbe
- red
- InChI
- 1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
- InChIKey
- KMJPYSQOCBYMCF-UHFFFAOYSA-N
- SMILES
- [O-][N+](=O)c1ccc(Nc2ccccc2-c3ccccc3)c4nonc14
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25-36/37/38 |
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| S-S?tze: |
26-45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa 363 and 381 (K
D = 4.4 μM), while 10058-F4 interaction site is located within aa residues 402 through 412 (K
D = 13 μM).
Biochem/physiol Actions
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.
N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 102)Lieferanten
- N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-aMine
- Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine
- N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine
- c-Myc Inhibitor II
- c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem
- 10074G5;10074 G5
- 10074-g
- 2,1,3-Benzoxadiazol-4-amine, N-[1,1'-biphenyl]-2-yl-7-nitro-
- 10074-G5 >=98% (HPLC)
- N-([1,1'-Biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine
- 10074G5,Inhibitor,10074 G5,10074-G-5,10074-G5,c-Myc,Autophagy,inhibit,Myc
- N-(2-Biphenylyl)-4-amino-7-nitrobenzo[c][1,2,5]oxadiazole
- 10074-G5, 10 mM in DMSO
- 10074-G5
- 413611-93-5
