2-chloro-3-fluoropyridin-4-aMine
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- CAS-Nr.
- 1227577-03-8
- Englisch Name:
- 2-chloro-3-fluoropyridin-4-aMine
- Synonyma:
- 2-chloro-3-fluoropyridin-4-aMine;2-Chloro-3-fluoro-4-pyridinamine;4-Amino-2-chloro-3-fluoropyridine;4-Pyridinamine, 2-chloro-3-fluoro-;2-Chloro-3-fluoro-pyridin-4-ylamine
- CBNumber:
- CB92598773
- Summenformel:
- C5H4ClFN2
- Molgewicht:
- 146.55
- MOL-Datei:
- 1227577-03-8.mol
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2-chloro-3-fluoropyridin-4-aMine Eigenschaften
- Siedepunkt:
- 271.9±35.0 °C(Predicted)
- Dichte
- 1.449±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.81±0.42(Predicted)
- Aggregatzustand
- powder
- Farbe
- Brown
- InChI
- InChI=1S/C5H4ClFN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9)
- InChIKey
- VUGYOFOYGPXOFL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(N)=C1F
2-chloro-3-fluoropyridin-4-aMine Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).
2-chloro-3-fluoropyridin-4-aMine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-chloro-3-fluoropyridin-4-aMine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 138)Lieferanten
- 4-Amino-2-chloro-3-fluoropyridine
- 2-Chloro-3-fluoro-pyridin-4-ylamine
- 2-chloro-3-fluoropyridin-4-aMine
- 4-Pyridinamine, 2-chloro-3-fluoro-
- 2-Chloro-3-fluoro-4-pyridinamine
- 1227577-03-8
