Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
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- CAS-Nr.
- 1195768-19-4
- Englisch Name:
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Synonyma:
- DABRAFENIB INT;Dalafenib intermediate 3;3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate;Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate;3-(2,6-difluorophenylsulfonylamideyl)-2-fluoromethyl benzoate;Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate;methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo...;Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate;Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
- CBNumber:
- CB92703779
- Summenformel:
- C14H10F3NO4S
- Molgewicht:
- 345.29
- MOL-Datei:
- 1195768-19-4.mol
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Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Eigenschaften
- Siedepunkt:
- 445.4±55.0 °C(Predicted)
- Dichte
- 1.507±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.68±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1S/C14H10F3NO4S/c1-22-14(19)8-4-2-7-11(12(8)17)18-23(20,21)13-9(15)5-3-6-10(13)16/h2-7,18H,1H3
- InChIKey
- COSCWKICERLCEK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(NS(C2=C(F)C=CC=C2F)(=O)=O)=C1F
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
Methyl 3-amino-2-fluorobenzoate was charged to the reactor, followed by dichloromethane. The contents were stirred and cooled to ~15°C, and pyridine was added. After that, the reactor contents were adjusted to ~15°C, and adding 2,6-diflurorobenzenesulfonyl chloride was started via an addition funnel. The temperature during addition was kept at <25°C. After complete addition, the reactor contents were warmed to 20-25°C and held overnight. Ethyl acetate was added, and dichloromethane was removed by distillation. Once distillation was complete, the reaction mixture was diluted again with ethyl acetate (5 vol) and concentrated. Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate was obtained through further purification.
![Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate](/NewsImg/2023-12-06/6383747428389984808211694.jpg "Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate")
Lager
Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 103)Lieferanten
- Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate
- Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate
- Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate
- Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
- DABRAFENIB INT
- methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo...
- Dalafenib intermediate 3
- 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate
- 3-(2,6-difluorophenylsulfonylamideyl)-2-fluoromethyl benzoate
- 1195768-19-4
- 1195765-23-0
- 1195765-20-7
