HLM006474
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- CAS-Nr.
- 353519-63-8
- Englisch Name:
- HLM006474
- Synonyma:
- CS-1224;HLM006474;HLM006474, 10 mM in DMSO;E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem;HLM006474,inhibit,HLM 006474,Early 2 Factor (E2F),Inhibitor,HLM-006474;7-((4-Ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl)-2-methylquinolin-8-ol;8-Quinolinol, 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-;7- (4-ethoxy-3-methylphenyl) (pyridine-2-ylamino) methyl) -2-methylquinoline-8-ol
- CBNumber:
- CB92715640
- Summenformel:
- C25H25N3O2
- Molgewicht:
- 399.48
- MOL-Datei:
- 353519-63-8.mol
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HLM006474 Eigenschaften
- Siedepunkt:
- 588.7±50.0 °C(Predicted)
- Dichte
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO:25.0(Max Conc. mg/mL);62.58(Max Conc. mM)
- pka
- 4.36±0.50(Predicted)
- Aggregatzustand
- Off-white solid
- Farbe
- White to off-white
- InChI
- 1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)
- InChIKey
- CYNZBLNMIJNBSF-UHFFFAOYSA-N
- SMILES
- CC1=CC(C(NC2=NC=CC=C2)C3=C(O)C(N=C(C)C=C4)=C4C=C3)=CC=C1OCC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
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HLM006474 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
HLM006474 is a non-selective inhibitor of the transcription factor E2F (IC
50 = 29.8 μM for E2F4). It inhibits DNA binding to E2F1, E2F2, and E2F4 in A375 melanoma cells when used at a concentration of 40 μM. HLM006474 (40 μM) decreases protein levels of E2F4 and cyclin D3 and induces apoptosis in A375 cells. It also induces apoptosis in MDA-MB-231, but not MCF-7, cells and inhibits the growth of cancer cells in a panel of 17 lung cancer cell lines (IC
50s = 15.5-75.1 μM). HLM006474 reduces tumor growth in retinoblastoma-prone Chx10Cre;Rb
fl/fl;p107
-/- mice and in an A375 mouse xenograft model when administered at a dose of 100 mg/kg and 2 mg per mouse, respectively.
Verwenden
HLM006474 has been used as an E2 factor(E2F) inhibitor in human nasopharyngeal carcinoma hone-1 cells and
T. annulata-infected TBL20 cells.
Allgemeine Beschreibung
A cell-permeable 8-hydroxyquinoline compound that is reported to inhibit nuclear E2F complexes DNA binding activity (IC
50 = 30 μM) and downregulate E2F expression in the melanoma cell line A375, resulting in eventual apoptosis induction without upregulating p53 expression as commonly seen with traditional chemotherapeutic agents, such as Cisplatin (Cat. No. 232120), doxorubicin (Cat. No. 324380), and VP-16 (Cat. No. 341205).
HLM006474 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
HLM006474 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 87)Lieferanten
- HLM006474
- E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem
- CS-1224
- 8-Quinolinol, 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-
- 7-((4-Ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl)-2-methylquinolin-8-ol
- HLM006474,inhibit,HLM 006474,Early 2 Factor (E2F),Inhibitor,HLM-006474
- 7- (4-ethoxy-3-methylphenyl) (pyridine-2-ylamino) methyl) -2-methylquinoline-8-ol
- HLM006474, 10 mM in DMSO
- 353519-63-8
