Sulfamerazinnatrium Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S7:Beh?lter dicht geschlossen halten.
S24:Berührung mit der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM.
In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory
Bacillus colonization in mice. It also prevents death of
Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.
Verwenden
Involved in characterization of chirosan membranes for the transport of drugs1,2,3
Weltgesundheitsorganisation (WHO)
Sulfamerazine sodium, a sulfonamide anti-infective agent, was
introduced several decades ago for the treatment of bacterial infections. The
importance of sulfonamides has subsequently decreased as a result of increasing
resistance and their replacement by antibiotics which are generally more active
and less toxic. The sulfonamides are known to cause serious adverse effects such
as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma
and dangerous adverse reactions affecting blood formation such as
agranulocytosis and haemolytic or aplastic anaemia. Sulfamerazine is still used in
some countries usually in combination with other sulfonamides.
Sicherheitsprofil
Moderately toxic by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.
Sulfamerazinnatrium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
