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BEKM-1

BEKM-1 Struktur
CAS-Nr.
Englisch Name:
BEKM-1
Synonyma:
BEKM-1;RPTDIKCSESYQCFPVCKSRFGKTNGRCVNGFCDCF;PEPTIDE INHIBITOR OF M-TYPE K+ CURRENT
CBNumber:
CB9306305
Summenformel:
C174H267N51O52S6
Molgewicht:
4097.68
MOL-Datei:
Mol file

BEKM-1 Eigenschaften

storage temp. 
−20°C
L?slichkeit
aqueous buffer: soluble
Aggregatzustand
lyophilized powder

Sicherheit

WGK Germany  3

BEKM-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This ERG channel inhibitor (FW = 4091.65 g/mol; CAS 524962-01-4; Soluble to 1 mg/mL in H2O), from the Central Asian scorpion Buthus eupeus, targets human KV11.1 Ether-a-go-go-Related Gene potassium ion currents. BeKm-1 inhibits hERG1 channels (IC50 = 3.3 nM), but has little or no effect, even at 100 nM, on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/3, and KCNQ4 channels. BeKm-1 shares a molecular scaffold (consisting of a short a-helix and a triple-stranded antiparallel b-sheet) in common with other short scorpion toxins. Site- directed mutagenesis identified Tyr-11, Lys-18, Arg-20, and Lys-23 as key residues for binding to hERG channels. All four are located in the a-helix and its following loop, whereas the canonical functional site of other short scorpion toxins lies within the b-sheet. BeKm-1 significantly prolongs QTc intervals in isolated rabbit hearts (4.7 at 10 nM, 16.3% at 100 nM), concentrations that inhibit hERG1 channels.

BEKM-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


BEKM-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 8)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alomone Labs --
info@alomone.com China 1241 58

  • BEKM-1
  • PEPTIDE INHIBITOR OF M-TYPE K+ CURRENT
  • RPTDIKCSESYQCFPVCKSRFGKTNGRCVNGFCDCF
  • Monovalent Ion Channels
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
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