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Larotrectinib Sulfate

Larotrectinib Sulfate Struktur
1223405-08-0
CAS-Nr.
1223405-08-0
Englisch Name:
Larotrectinib Sulfate
Synonyma:
(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate;(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate (1:1);LOX-101;Loxo-101(S);LOX-101(sulfate);ARRY 470) sulfate;Larotinib sulfate;LOXO-101 (sulfate);Larotrectinib sulfate;Larotrectinib(LOXO 101
CBNumber:
CB93067010
Summenformel:
C21H24F2N6O6S
Molgewicht:
526.52
MOL-Datei:
1223405-08-0.mol

Larotrectinib Sulfate Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
≥18.47 mg/mL in DMSO; ≥2.14 mg/mL in EtOH; ≥29.65 mg/mL in H2O
Aggregatzustand
solid
Farbe
Light yellow to brown
Stabilit?t:
Hygroscopic
InChIKey
PXHANKVTFWSDSG-RZOMTXEQNA-N
SMILES
S(O)(O)(=O)=O.FC1C=CC(F)=CC=1[C@H]1CCCN1C1C=CN2N=CC(NC(N3C[C@@H](O)CC3)=O)=C2N=1 |&1:13,29,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Larotrectinib Sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LOXO-101 (sulfate) (or Larotrectinib Sulfate)  is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). 

Verwenden

Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).

Mechanism of action

Larotrectinib sulfate functions as an inhibitor of TRKs including TRKA, B, and C. In in vitro and in vivo tumor models, larotrectinib demonstrated anti-tumor activity in cells with constitutive activation of TRK proteins resulting from gene fusions, deletion of a protein regulatory domain, or in cells with TRK protein overexpression. Larotrectinib had minimal activity in cell lines with point mutations in the TRKA kinase domain, including the clinically identified acquired resistance mutation, G595R. Point mutations in the TRKC kinase domain with clinically identified acquired resistance to larotrectinib include G623R, G696A, and F617L.

Larotrectinib Sulfate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Larotrectinib Sulfate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 199)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhengzhou Anhuida Chemical Co., Ltd
+8615903659408
admin@ahdchem.com China 286 58
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+86-010-67886402 +8613611125266
market@hopelife.cn China 72 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368
sales@sjar-tech.com China 529 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Ningbo Nuobai Pharmaceutical Co., Ltd.
18758416982
Fisheryu@nbpharm.com China 13 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10403 58
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com CHINA 954 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 +86-17392581500
1015@dideu.com China 3992 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 9542 58

  • LOXO-101 (sulfate)
  • Larotrectinib/LOXO 101/ARRY 470 sulfate
  • ARRY 470) sulfate
  • Larotrectinib sulfate
  • Larotrectinib(LOXO 101
  • Larotrectinib (LOXO-101) sulfate
  • 1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-, sulfate (1:1)
  • ARRY-470, Larotrectinib
  • LOX-101
  • Loxo-101(S)
  • LOX-101(sulfate)
  • Larotrectinib sulfate(LOXO101)
  • (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate
  • Larotrectinib sulfate salt
  • 2H4]-Larotrectinib sulfate salt
  • LOXO-101 sulfate|||Larotrectinib (LOXO-101) sulfate|||Larotrectinib|||LOXO-101 (sulfate)|||ARRY-470|||ARRY-470 (sulfate)
  • Larotinib sulfate
  • Larotrectinib sulfate, 10 mM in DMSO
  • Larotrectinib sulphate
  • LOXO-101 sulfate (LOXO101 sulfate
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-pyrrolidine-1-carboxamide sulfate
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate (1:1)
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate
  • 1223405-08-0
  • C21H22F2N6O2H2SO4
  • C21H24F2N6O6S
  • API
  • LOXO-101
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